Soft tissue tumors - Anaplastic rhabdomyosarcoma

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Soft tissue tumors

Skeletal muscle

Anaplastic rhabdomyosarcoma

Reviewer: Vijay Shankar, M.D. (see Reviewers page)
Revised: 22 February 2013, last major update November 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

Terminology
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● In children (but not adults), includes cases previously called pleomorphic rhabdomyosarcoma
● Not a WHO diagnosis
● Most cases represent a variant of embryonal rhabdomyosarcoma

Treatment and prognosis
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● Poor prognosis, particularly if anaplastic cells are aggregated in a clone-like cluster

Case reports
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● 13 year old girl with mass in cervix (Arch Gynecol Obstet 2004;270:278)

Micro description
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● Cells have enlarged, pleomorphic, hyperchromatic nuclei
● Atypical polar mitotic figures

Micro images
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Cluster of cells with enlarged, pleomorphic, hyperchromatic nuclei (Mod Pathol 2001;14:506)

End of Soft tissue tumors > Skeletal muscle > Anaplastic rhabdomyosarcoma

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