Soft tissue
Fibroblastic / myofibroblastic tumors

Author: Komal Arora, M.D.

Revised: 29 January 2018, last major update July 2012

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Angiofibroma [title]

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Cite this page: Arora, K. Angiofibroma. website. Accessed February 16th, 2019.
Case reports
Microscopic (histologic) images

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Case of the Week #311

Differential diagnosis
  • Cellular angiofibroma: usually in genital region, more cellular, usually ER+, PR+
  • Low grade fibromyxoid sarcoma: often > 6 cm and infiltrative, 45% have epithelioid areas, 40% contain poorly formed but large collagen rosettes
  • Low grade myxofibrosarcoma: infiltrative borders, often sends out long tentacles, more solid areas are often seen similar to typical undifferentiated pleomorphic sarcom; has curvilinear vessels (thick walled with broad arc) with condensation of cells around vessels
  • Myxoid liposarcoma: prominent chicken wire vasculature, numerous signet ring lipoblasts particularly at periphery of lobules, mucoid matrix rich in hyaluronidase sensitive acid mucopolysaccharides, may have large mucoid pools, S100+
  • Solitary fibrous tumor: fibroblast like cells with patternless pattern, thick bands of collagen and prominent branching, hyalinized vessels; CD34+, CD99+