Soft tissue
Fibroblastic / myofibroblastic

Topic Completed: 1 July 2012

Minor changes: 14 September 2020

Copyright: 2002-2020,, Inc.

PubMed Search: Angiofibroma [title]

Komal Arora, M.D.
Page views in 2019: 4,594
Page views in 2020 to date: 3,354
Cite this page: Arora K. Angiofibroma. website. Accessed September 20th, 2020.
Case reports
  • 38 year old woman with ankle mass (Case #311)
Microscopic (histologic) images

Case #311

Case #311

Differential diagnosis
  • Cellular angiofibroma: usually in genital region, more cellular, usually ER+, PR+
  • Low grade fibromyxoid sarcoma: often > 6 cm and infiltrative, 45% have epithelioid areas, 40% contain poorly formed but large collagen rosettes
  • Low grade myxofibrosarcoma: infiltrative borders, often sends out long tentacles, more solid areas are often seen similar to typical undifferentiated pleomorphic sarcom; has curvilinear vessels (thick walled with broad arc) with condensation of cells around vessels
  • Myxoid liposarcoma: prominent chicken wire vasculature, numerous signet ring lipoblasts particularly at periphery of lobules, mucoid matrix rich in hyaluronidase sensitive acid mucopolysaccharides, may have large mucoid pools, S100+
  • Solitary fibrous tumor: fibroblast like cells with patternless pattern, thick bands of collagen and prominent branching, hyalinized vessels; CD34+, CD99+
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