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Soft tissue Tumors

Fibroblastic / myofibroblastic tumors

Angiofibroma


Reviewer: Komal Arora, M.D. (see Reviewers page)
Revised: 8 May 2014, last major update July 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

Case reports
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● 38 year old woman with ankle mass (Case of the Week #311)

Micro images
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Case of the Week #311

Differential diagnosis
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Cellular angiofibroma: usually in genital region, more cellular, usually ER+, PR+
Low grade fibromyxoid sarcoma: often > 6 cm and infiltrative, 45% have epithelioid areas, 40% contain poorly formed but large collagen rosettes
Low grade myxofibrosarcoma: infiltrative borders, often sends out long tentacles, more solid areas are often seen similar to typical undifferentiated pleomorphic sarcom; has curvilinear vessels (thick walled with broad arc) with condensation of cells around vessels
Myxoid liposarcoma: prominent chicken wire vasculature, numerous signet ring lipoblasts particularly at periphery of lobules, mucoid matrix rich in hyaluronidase sensitive acid mucopolysaccharides, may have large mucoid pools, S100+
Solitary fibrous tumor: fibroblast like cells with patternless pattern, thick bands of collagen and prominent branching, hyalinized vessels; CD34+, CD99+

End of Soft Tissue Tumors > Fibroblastic / myofibroblastic tumors > Angiofibroma


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