Soft tissue
Smooth muscle
Bizarre leiomyoma

Topic Completed: 1 November 2012

Revised: 26 March 2019

Copyright: 2002-2018,, Inc.

PubMed Search: Bizarre leiomyoma

Vijay Shankar, M.D.
Page views in 2018: 1,085
Page views in 2019 to date: 1,230
Cite this page: Shankar V. Bizarre leiomyoma. website. Accessed September 18th, 2019.
  • Also called symplastic, atypical, apoplectic leiomyoma
Clinical features
Case reports
Clinical images

Images hosted on other servers:

Scrotal mass

Thigh nodule

Microscopic (histologic) description
  • Large, atypical nuclei in otherwise normal appearing leiomyoma
  • No/rare mitotic figures
  • Suggested classification for vulvar tumors is based on number of features below (0 - 1: leiomyoma, 2: atypical leiomyoma, 3 - 4: leiomyosarcoma)
    • 5+ cm in greatest dimension
    • Infiltrative margins
    • 5+ mitotic figures per 10 HPF
    • Moderate to severe cytologic atypia (Am J Surg Pathol 1996;20:779)
Microscopic (histologic) images

Images hosted on other servers:

Smooth muscle cells with focal atypia

68 year old woman with thigh nodule (figures 2 - 5)

72 year old woman with nasal obstruction, rhinorrea and epistaxis

Negative stains
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