Soft tissue
Fibroblastic / myofibroblastic
Desmoplastic fibroblastoma


Topic Completed: 1 July 2012

Minor changes: 25 September 2020

Copyright: 2002-2020, PathologyOutlines.com, Inc.

PubMed Search: Desmoplastic fibroblastoma


Komal Arora, M.D.
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Cite this page: Arora K. Desmoplastic fibroblastoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/softtissuecollagenousfibroma.html. Accessed September 26th, 2020.
Definition / general
  • Fibroblastic lesion centered in subcutaneous tissue with reactive fibroblasts, low cellularity and abundant collagen (Hum Pathol 1998;29:676)
  • Also called collagenous fibroma
Epidemiology
  • Rare benign lesion of adult men (70% between ages 40 and 69 years)
Sites
  • Usually upper extremities, back, feet
Case reports
Treatment
  • Conservative excision, does not recur or metastasize
Gross description
  • Usually 1 - 4 cm, well circumscribed, may be lobulated, has firm and homogeneous gray cut surface resembling cartilage
Gross images

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Well circumscribed tumor

Microscopic (histologic) description
  • Paucicellular, bland spindled (stellate) and reactive appearing fibroblasts and myofibroblasts separated by abundant collagen with variable myxoid stroma
  • Fibroblasts have amphophilic cytoplasm, vesicular nuclei and distinct nucleoli
  • 70% of cases involve subcutis, 25% extend into skeletal muscle
Microscopic (histologic) images

AFIP images

Large, reactive appearing spindled fibroblasts in fibrous matrix

Focus of low cellularity and dense collagen

More cellular area with reactive type fibroblasts

Positive stains
Negative stains
Electron microscopy description
Molecular / cytogenetics description
Differential diagnosis
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