Soft tissue
Fibroblastic / myofibroblastic
Eosinophilic fasciitis

Topic Completed: 1 July 2012

Minor changes: 10 September 2020

Copyright: 2002-2020,, Inc.

PubMed Search: Eosinophilic fasciitis

Komal Arora, M.D.
Page views in 2019: 491
Page views in 2020 to date: 371
Cite this page: Arora K. Eosinophilic fasciitis. website. Accessed November 27th, 2020.
Definition / general
  • Rare fibrosing disorder with scleroderma-like induration of distal extremities
  • Diffuse fasciitis with fibrosis, eosinophilia and inflammation of skin, subcutaneous tissue and fascia
  • Not a WHO diagnosis
  • First described by Shulman (Trans Assoc Am Physicians 1975;88:70) [also called Shulman syndrome]
  • Mean age 50 years, 75% women
  • Eosinophilic-myalgia syndrome is different, and is associated with contaminated L-tryptophan, myalgia and neuritis (Hum Pathol 1992;23:429)
  • Shulman's syndrome tends to involve the subcutis alone and the eosinophilia-myalgia syndrome tends to be a pancutaneous-subcutaneous process (eMedicine, J Am Acad Dermatol 1992;26:95)
  • Presence of morphea-like skin lesions is associated with residual fibrosis (Clin Rheumatol 2007;26:1445)
Case reports
Clinical images

Images hosted on other servers:

Sclerotic slightly
pigmented plaques
with orange
skin aspect

Gross description
  • Woody, firm subcutaneous mass
Microscopic (histologic) description
  • Eosinophils, lymphocytes, mast cells and histiocytes in fibrotic or fibromyxoid stroma of subcutis and fascia
Microscopic (histologic) images

Images hosted on other servers:

Thickening of fascia with chronic inflammatory infiltrate

Inflammatory infiltrate in deep subcutis

Additional references
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