Soft tissue
Fibroblastic / myofibroblastic tumors
Eosinophilic fasciitis

Author: Komal Arora, M.D. (see Authors page)

Revised: 15 August 2016, last major update July 2012

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Eosinophilic fasciitis

Definition / General
  • Rare fibrosing disorder with scleroderma-like induration of distal extremities
  • Diffuse fasciitis with fibrosis, eosinophilia and inflammation of skin, subcutaneous tissue and fascia
  • Not a WHO diagnosis
  • First described by Shulman (Trans Assoc Am Physicians 1975;88:70) [also called Shulman’s syndrome]
Epidemiology
  • Mean age 50 years, 75% women
  • Eosinophilic-myalgia syndrome is different, and is associated with contaminated L-tryptophan, myalgia and neuritis (Hum Pathol 1992;23:429)
  • Shulman's syndrome tends to involve the subcutis alone and the eosinophilia-myalgia syndrome tends to be a pancutaneous-subcutaneous process (eMedicine, J Am Acad Dermatol 1992;26:95)
  • Presence of morphea-like skin lesions is associated with residual fibrosis (Clin Rheumatol 2007;26:1445)
Case Reports
Treatment
Clinical Images

Images hosted on other servers:

Sclerotic slightly pigmented
plaques with orange skin aspect

Gross Description
  • Woody, firm subcutaneous mass
Micro Description
  • Eosinophils, lymphocytes, mast cells and histiocytes in fibrotic or fibromyxoid stroma of subcutis and fascia
Micro Images

Images hosted on other servers:

Thickening of fascia with chronic inflammatory infiltrate

Inflammatory infiltrate in deep subcutis

Additional References