Soft tissue
Smooth muscle
Epithelioid leiomyosarcoma

Author: Vijay Shankar, M.D. (see Authors page)

Revised: 29 September 2016, last major update November 2012

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Epithelioid leiomyosarcoma [title] soft tissue

Cite this page: Epithelioid leiomyosarcoma. website. Accessed October 23rd, 2016.
Definition / General
Case Reports
Clinical Images

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MRI, intraabdominal mass

Gross Images

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Rectal tumor

Micro Description
  • Round / polygonal cells with eosinophilic and vacuolated cytoplasm, vesicular nuclei
  • Arranged in sheets with focal spindle cells
Micro Images

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Courtesy of Mark R. Wick, M.D.

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Various images


Rectal tumor w/ osteoclast-like giant cells

Various images

Cytology Description
  • Mononuclear, binucleated or multinucleated cells with eccentric nuclei and dense to vacuolar cytoplasm (Acta Cytol 1997;41:1801)
  • Also highly cellular smears with many single polygonal cells having eccentric, malignant nuclei and a characteristic clear quality to the cytoplasm in pap-stained material (Diagn Cytopathol 1994;11:321)
Positive Stains
Electron Microscopy Description
  • Abundant actin-type filaments in cytoplasm of some cells, glycogen
Electron Microscopy Images

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Differential Diagnosis