Soft tissue
Smooth muscle
Epithelioid leiomyosarcoma

Author: Vijay Shankar, M.D.

Revised: 10 September 2018, last major update November 2012

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Epithelioid leiomyosarcoma [title] soft tissue

Cite this page: Shankar, V. Epithelioid leiomyosarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/softtissueepithelioidleiomyosarcoma.html. Accessed November 14th, 2018.
Definition / general
Case reports
Gross images

Images hosted on other servers:

Rectal tumor

Microscopic (histologic) description
  • Round / polygonal cells with eosinophilic and vacuolated cytoplasm, vesicular nuclei
  • Arranged in sheets with focal spindle cells
Microscopic (histologic) images

Images hosted on PathOut server:

Contributed by Mark R. Wick, M.D.

Various images



Images hosted on other servers:

Various images

Rectal tumor w/ osteoclast-like giant cells

Various images

Cytology description
  • Mononuclear, binucleated or multinucleated cells with eccentric nuclei and dense to vacuolar cytoplasm (Acta Cytol 1997;41:1801)
  • Also highly cellular smears with many single polygonal cells having eccentric, malignant nuclei and a characteristic clear quality to the cytoplasm in pap-stained material (Diagn Cytopathol 1994;11:321)
Positive stains
Electron microscopy description
  • Abundant actin-type filaments in cytoplasm of some cells, glycogen
Differential diagnosis