Soft tissue
Smooth muscle
Epithelioid leiomyosarcoma

Author: Vijay Shankar, M.D.

Revised: 10 September 2018, last major update November 2012

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Epithelioid leiomyosarcoma [title] soft tissue

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Cite this page: Shankar, V. Epithelioid leiomyosarcoma. website. Accessed March 19th, 2019.
Definition / general
Case reports
Gross images

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Rectal tumor

Microscopic (histologic) description
  • Round / polygonal cells with eosinophilic and vacuolated cytoplasm, vesicular nuclei
  • Arranged in sheets with focal spindle cells
Microscopic (histologic) images

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Contributed by Mark R. Wick, M.D.

Various images

Images hosted on other servers:

Various images

Rectal tumor w/ osteoclast-like giant cells

Various images

Cytology description
  • Mononuclear, binucleated or multinucleated cells with eccentric nuclei and dense to vacuolar cytoplasm (Acta Cytol 1997;41:1801)
  • Also highly cellular smears with many single polygonal cells having eccentric, malignant nuclei and a characteristic clear quality to the cytoplasm in pap-stained material (Diagn Cytopathol 1994;11:321)
Positive stains
Electron microscopy description
  • Abundant actin-type filaments in cytoplasm of some cells, glycogen
Differential diagnosis
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