• Features identical to intraosseous aneurysmal bone cyst
• Rapidly growing, benign mass of deep soft tissue of upper extremities, thigh or groin, without involvement of adjacent bones
• Mean age 28 years, range 8-37 years
• May recur locally if incompletely excised

• 10 year old girl with shoulder pain (Oncol Lett 2012;3:545)

• Median 4 cm, range 2.5-9 cm, surrounded by thin rim of bone (Am J Surg Pathol 2002;26:64)
• Hemorrhagic cystic spaces with fibrous septa

Shoulder

• Cystic spaces filled with blood
• Fibrous septa composed of fibroblasts, osteoclast-type giant cells, woven bone

Shoulder

• 46,XY, t(17;17)(p13;q12), similar to intraosseous aneurysmal bone cyst
• Also t(16;17)(q22;p13)
• USP6 locus rearrangement on chromosome 17p13 (J Bone Joint Surg Am 2011;93:e45)

• Extraskeletal osteosarcoma

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