Soft tissue
Extraskeletal bone tumors
Extraskeletal chondrosarcoma

Author: Vijay Shankar, M.D. (see Authors page)

Revised: 11 August 2016, last major update November 2012

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Extraskeletal chondrosarcoma [title]

See also: Mesenchymal chondrosarcoma, Myxoid chondrosarcoma

Cite this page: Extraskeletal chondrosarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/softtissueeskchondrosarcoma.html. Accessed December 5th, 2016.
Definition / General
  • Less aggressive than similar bone tumor
  • Usually adult extremities; also children and trunk
  • Metastases to lung
  • Embryonal chondrosarcoma: Rare, primitive appearance
Gross Images

Images hosted on PathOut servers:

Hyaline, courtesy of Mark R. Wick, M.D.



Images hosted on other servers:

Thigh tumor

Fallopian tube tumor

Micro Description
  • Usually myxoid
  • Cords of small cells with acidophilic cytoplasm, occasional vacuoles, usually in myxoid stroma
  • Usually no obvious chondrocytes
Micro Images

Images hosted on PathOut servers:

Clear cell, courtesy of Mark R. Wick, M.D.



Images hosted on other servers:

Fallopian tube tumor

Positive Stains
Negative Stains
Electron Microscopy Description
  • Well developed endoplasmic reticulum, cytoplasmic filaments, glycogen
Molecular / Cytogenetics Description
  • t(9;22)(q22-31;q11-12): CHN-EWS fusion gene, is consistent marker for extraskeletal myxoid chondrosarcoma (Mod Pathol 1995;8:765)