Soft tissue
Extraskeletal bone tumors
Myxoid chondrosarcoma

Author: Vijay Shankar, M.D.

Revised: 30 January 2018, last major update November 2012

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Myxoid chondrosarcoma [title]

See also: Extraskeletal chondrosarcoma, Mesenchymal chondrosarcoma

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Cite this page: Shankar, V. Myxoid chondrosarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/softtissueeskchondrosarcomamyxoid.html. Accessed July 19th, 2019.
Definition / general
  • Rare, first described in 1972
  • 50 - 65% males, median age 50 - 52 years, range 6 - 89 years
  • 80% in proximal extremities or limb girdles, 20% in trunk
  • Local recurrence in 48%, metastases in 46%
  • Survival of 90% at 5 years, 70 - 78% at 10 years (Mod Pathol 2000;13:900)
Prognostic factors
  • Adverse prognostic factors: older age, larger tumor size (> 10 cm), proximal extremity / limb girdle location, anaplastic cytology (Am J Surg Pathol 1999;23:636)
Case reports
Clinical images

Images hosted on PathOut servers:

Case of the Week #366

Thigh, MRI, courtsey of Mark R. Wick, M.D.

Gross description
  • Median 7 - 10 cm (range 1 - 25 cm) in deep subcutaneous or deeper soft tissue
Gross images

Images hosted on PathOut servers:

Case of the Week #366



Images hosted on other servers:

Fallopian tube nodule

Thigh tumor

Microscopic (histologic) description
  • Anastamosing cords of neoplastic cells in a myxoid matrix
  • Most have low cellularity
  • May have focal hypercellular areas and > 2 mitotic figures / 10 HPF
  • May have rhabdoid features if INI1 negative
Microscopic (histologic) images

Images hosted on PathOut servers:

Case of the Week #366



CD117



Myxoid type, courtesy of Mark R. Wick, M.D.



Images hosted on other servers:

Uterine adnexa

Thigh tumor



Asymptomatic lung mass with severe anemia

Cytology images

Images hosted on other servers:

Thigh tumor

Positive stains
Molecular / cytogenetics description
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