• Adults, extremities
• May occur after Xray exposure
• 60% mortality, worse than chondrosarcoma
• Subtypes: osteoblastic, chondroblastic, fibroblastic, MFH-like, telangiectactic, well-differentiated (parosteal)

• 30 year old man with chest wall mass (BMC Cancer 2010;10:645)
• 56 year old man with cutaneous tumor on scar of previous bone graft (Ann Dermatol 2011;23:S160)
• 62 year old woman with well-differentiated tumor arising from retroperitoneum that recurred as anaplastic spindle cell sarcoma. (Case Rep Med 2010;2010:327591)
• 79 year old man with upper arm tumor (Oncol Lett 2011;2:75)

Skin of lower abdomen

Retroperitoneal mass

Upper arm mass

• Osteoid and bone formation produced by tumor cells, without interposition of cartilage

Upper arm

Chest wall

Retroperitoneal mass

Cutaneous tumor on scar of previous bone graft

• Myositis ossificans: no nuclear atypia, zonal
• Other sarcomas producing metaplastic bone: MFH, synovial sarcoma, fibrosarcoma

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