Soft tissue
Extraskeletal bone tumors
Osteosarcoma


Topic Completed: 1 November 2012

Minor changes: 16 September 2020

Copyright: 2002-2020, PathologyOutlines.com, Inc.

PubMed Search: Extraskeletal osteosarcoma [title]

Vijay Shankar, M.D.
Page views in 2019: 1,634
Page views in 2020 to date: 2,014
Cite this page: Shankar V. Osteosarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/softtissueeskosteo.html. Accessed October 25th, 2020.
Definition / general
  • Adults, extremities
  • May occur after Xray exposure
  • 60% mortality, worse than chondrosarcoma
  • Subtypes: osteoblastic, chondroblastic, fibroblastic, MFH-like, telangiectactic, well-differentiated (parosteal)
Case reports
Clinical images

Contributed by Mark R. Wick, M.D.
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Upper arm x-ray



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Skin of lower abdomen

Gross images

Case #370

Case #1: 75 year old man

Case #2: 55 year old woman



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Retroperitoneal mass

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Upper arm mass

Microscopic (histologic) description
  • Osteoid and bone formation produced by tumor cells, without interposition of cartilage
Microscopic (histologic) images

Case of the Week #370 - Case #1

CK negative

Vimentin positive



Case of the Week #370 - Case #2:

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Contributed by Mark R. Wick, M.D.
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Upper arm



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Cutaneous tumor on scar of previous bone graft

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Upper arm



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Chest wall

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Retroperitoneal mass

Differential diagnosis
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