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Skin / Soft Tissue Tumors
Fibrohistiocytic tumors - general
Author: Nat Pernick, M.D., PathologyOutlines.com, Inc.
Reviewer: David Lucas, M.D., University of Michigan Health Systems (January 2009)
Revised: 26 June 2009, last major update June 2009
Definition
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● Tumors composed of cells with morphologic features of fibroblasts and histiocytes
● Cells are actually fibroblasts, myofibroblasts or primitive mesenchymal cells
● Cells are NOT histiocytes, but may exhibit phagocytic properties, including phagocytosis of neutrophils
● Tumor cells may express histiocytic markers - CD68, alpha-1-antitrypsin or alpha-1-antichymotrypsin
Classification
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WHO classification (2002) and ICD-0 codes follow:
Benign
Giant cell tumour of tendon sheath 9252/0
Diffuse-type giant cell tumour 9251/0
Deep benign fibrous histiocytoma 8830/0
Intermediate (rarely metastasizing)
Plexiform fibrohistiocytic tumour 8835/1
Giant cell tumour of soft tissues 9251/1
Malignant
Pleomorphic ‘MFH’ / Undifferentiated pleomorphic sarcoma 8830/3
Giant cell ‘MFH’ / Undifferentiated pleomorphic sarcoma with giant cells 8830/3
Inflammatory ‘MFH’ / Undifferentiated pleomorphic sarcoma with prominent inflammation 8830/3
References: Fletcher: Pathology and Genetics of Tumours of Soft Tissue and Bone, Vol 5), link (PDF)
End of Skin / Soft Tissue Tumors > Fibrohistiocytic tumors - general
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