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Soft Tissue Tumors


Fibrohistiocytic tumors - general

Reviewer: Vijay Shankar, M.D. (see Reviewers page)
Revised: 24 October 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.


● Tumors composed of cells with morphologic features of fibroblasts and histiocytes
● Cells are actually fibroblasts, myofibroblasts or primitive mesenchymal cells
● Cells are NOT histiocytes, but may exhibit phagocytic properties, including phagocytosis of neutrophils
● Tumor cells may express histiocytic markers CD68, alpha-1-antitrypsin or alpha-1-antichymotrypsin


WHO Classification (2006) of fibrous, fibrohistiocytic and histiocytic tumours occurring in skin (superficial) and ICD-O codes:

      ● Dermatomyofibroma: 8824/0
      ● Infantile myofibromatosis: 8824/1
      ● Sclerotic fibroma: 8823/0
      ● Pleomorphic fibroma: 8832/0
      ● Giant cell fibroblastoma: 8834/1
      ● Dermatofibrosarcoma protuberans: 8832/3
      ● Dermatofibroma (fibrous histiocytoma): 8832/0

WHO classification (2002) of fibrohistiocytic tumors of soft tissue (deep) and ICD-0 codes:

      ● Giant cell tumour of tendon sheath: 9252/0
      ● Diffuse-type giant cell tumour: 9251/0
      ● Deep benign fibrous histiocytoma: 8830/0

Intermediate (rarely metastasizing)
      ● Plexiform fibrohistiocytic tumour: 8835/1
      ● Giant cell tumour of soft tissues: 9251/1

      ● Pleomorphic ‘MFH’ / Undifferentiated pleomorphic sarcoma: 8830/3
      ● Giant cell ‘MFH’ / Undifferentiated pleomorphic sarcoma with giant cells: 8830/3
      ● Inflammatory ‘MFH’ / Undifferentiated pleomorphic sarcoma with prominent inflammation: 8830/3

● References: Fletcher: Pathology and Genetics of Tumours of Soft Tissue and Bone, FLetcher-Chapter 5 (PDF), Fletcher-Chapter 3 (PDF)

End of Soft Tissue Tumors > Fibrohistiocytic > Fibrohistiocytic tumors - general

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