Soft Tissue Tumors - Fibrohistiocytic tumors

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Soft Tissue Tumors

Fibrohistiocytic

Fibrohistiocytic tumors - general

Reviewer: Vijay Shankar, M.D. (see Reviewers page)
Revised: 24 October 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Tumors composed of cells with morphologic features of fibroblasts and histiocytes
● Cells are actually fibroblasts, myofibroblasts or primitive mesenchymal cells
● Cells are NOT histiocytes, but may exhibit phagocytic properties, including phagocytosis of neutrophils
● Tumor cells may express histiocytic markers CD68, alpha-1-antitrypsin or alpha-1-antichymotrypsin

Classification
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WHO Classification (2006) of fibrous, fibrohistiocytic and histiocytic tumours occurring in skin (superficial) and ICD-O codes:

● Dermatomyofibroma: 8824/0
● Infantile myofibromatosis: 8824/1
● Sclerotic fibroma: 8823/0
● Pleomorphic fibroma: 8832/0
● Giant cell fibroblastoma: 8834/1
● Dermatofibrosarcoma protuberans: 8832/3
● Dermatofibroma (fibrous histiocytoma): 8832/0

WHO classification (2002) of fibrohistiocytic tumors of soft tissue (deep) and ICD-0 codes:

Benign
● Giant cell tumour of tendon sheath: 9252/0
● Diffuse-type giant cell tumour: 9251/0
● Deep benign fibrous histiocytoma: 8830/0

Intermediate (rarely metastasizing)
● Plexiform fibrohistiocytic tumour: 8835/1
● Giant cell tumour of soft tissues: 9251/1

Malignant
● Pleomorphic ‘MFH’ / Undifferentiated pleomorphic sarcoma: 8830/3
● Giant cell ‘MFH’ / Undifferentiated pleomorphic sarcoma with giant cells: 8830/3
● Inflammatory ‘MFH’ / Undifferentiated pleomorphic sarcoma with prominent inflammation: 8830/3

● References: Fletcher: Pathology and Genetics of Tumours of Soft Tissue and Bone, FLetcher-Chapter 5 (PDF), Fletcher-Chapter 3 (PDF)

End of Soft Tissue Tumors > Fibrohistiocytic > Fibrohistiocytic tumors - general

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