Soft tissue
Fibroblastic / myofibroblastic tumors
Normal histology of soft tissue

Topic Completed: 1 July 2012

Minor changes: 21 March 2019

Copyright: 2002-2018,, Inc.

PubMed Search: Normal histology of soft tissue [title]

Komal Arora, M.D.
Page views in 2019: 2,413
Page views in 2020 to date: 1,283
Cite this page: Arora K. Normal histology of soft tissue. website. Accessed July 2nd, 2020.
Definition / general
  • Fibrous tissue consists of fibroblasts and extracellular matrix
  • Extracellular matrix consists of collagen, elastin and ground substance

Fibrous tissue:
  • Loose or dense
  • Dense fibrous tissue includes tendons (connect muscle to bone), ligaments (connect bones or cartilage to each other), aponeuroses (ribbon like tendinous expansion)

  • Spindled (along collagen fibers) to stellate (star shaped-in myxoid areas)
  • Produce various collagens
  • Positive for vimentin, actin

  • Quiescent stage of fibroblasts

  • Modified fibroblasts with multiple possible origins (see diagram below), including transition from fibroblasts during tissue repair (J Invest Dermatol 2007;127:526)
  • Features are intermediate between fibroblasts and smooth muscle cells
Diagrams / tables

Images hosted on other servers:

Myofibroblast progenitors

Microscopic (histologic) images

Images hosted on PathOut servers:

Myofibroma: interface
of myofibroblastic tumor
with normal collagen

Images hosted on other servers:

NIH / 3T3 Mouse fibroblasts in cell culture

Extracellular matrix compliance
controls development of the
myofibroblast phenotype in
three-dimensional collagen gels

Back to top