Soft tissue Tumors - Gardner type fibroma

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Soft tissue Tumors

Fibroblastic / myofibroblastic tumors

Gardner type fibroma

Reviewer: Komal Arora, M.D. (see Reviewers page)
Revised: 20 July 2012, last major update July 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Benign soft tissue lesion with thick, haphazard collagen and bland fibroblasts that entrap adjacent tissue
● 90% associated with FAP / Gardner’s syndrome / APC germline mutation
● Uncommon
● Affects infants, children and teenagers
● May be initial diagnostic clue to Gardner’s syndrome and APC mutations (Am J Surg Pathol 2001;25:645)
● 45% develop desmoid-type fibromatosis
● Similar histology to nuchal-type fibroma (Pathol Int 2004;54:523, Am J Surg Pathol 2000;24:1563)

Sites:
● Superficial or deep soft tissue
● Various sites

Case reports
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● Post-surgical desmoid tumor in Gardner’s syndrome patient (J Neurooncol 2009;91:107)

Gross description
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● 1-10 cm, poorly circumscribed, firm, rubbery, plaque-like, white to tan-pink cut surface with trapped fat in yellow areas

Micro description
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● Thick, haphazardly arranged collagen bundles, hypocellular bland fibroblasts, small blood vessels, plaque-like growth pattern with infiltration of adjacent structures

Micro images
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Gardner's Fibroma / Nuchal fibroma

Gardner associated fibromas and severe polyposis in 4 year old with FAP

Positive stains
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● CD34, cyclin D1, vimentin, nuclear beta-catenin (64%)

Negative stains
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● Muscle specific actin, smooth muscle actin, desmin, ER, PR

Additional references
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● Am J Surg Pathol 2007;31:410, Pathologe 2010;31:97, Stanford University

End of Soft Tissue Tumors > Fibroblastic / myofibroblastic tumors > Gardner type fibroma

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