Soft tissue
Fibrohistiocytic tumors
Giant cell tumor of soft tissue

Author: Vijay Shankar, M.D. (see Authors page)

Revised: 14 September 2016, last major update August 2012

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Giant cell tumor of soft tissue

Cite this page: Giant cell tumor of soft tissue. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/softtissuegct.html. Accessed December 7th, 2016.
Definition / General
Clinical Features
  • Rare, usually age 40+ years, rare in children
  • Usually superficial soft tissue of extremities (70%); rarely breast, mediastinum, groin, surgical scars
  • Presents as painless growing mass
Case Reports
Treatment
  • Complete excision with negative margins
  • Recurs in 12% (associated with incomplete excision)
  • Rare metastases and death
Clinical Images

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54 year old man

Large, smooth, firm, erythematous nodule on thigh

Gross Description
  • Up to 10 cm, usually dermis or subcutis, 30% are below superficial fascia
  • Well circumscribed, nodular, fleshy, red-brown-gray, gritty at periphery due to calcification
Gross Images

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Mediastinal mass

Micro Description
  • Multinodular with fibrous tissue containing siderophages separating nodules
  • Nodules contain round / oval mononuclear cells and multinucleated osteoclast-like giant cells with similar nuclei
  • Mononuclear cells are epitheloid or spindled, with eosinophilic cytoplasm and central nuclei
  • Stroma is vascularized; up to 30 mitotic figures / 10 HPF
  • Often metaplastic bone, blood lakes, vascular invasion
  • Occasionally fascicular pattern with focal storiform arrangement of spindle cells
  • No / rare atypia, pleomorphism or necrosis
Micro Images

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Resembles giant cell tumor of bone, with osteoclast-like giant cells but at most mild pleomorphism



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Chondroid pattern and osteoid pattern

Mediastinal mass

Osteoclast-like giant cells

Cytology Description
  • Numerous osteoclast-like giant cells and mononuclear cells with bland and vesicular nuclei
  • Occasional / rare fragment of branching vasculature, mitotic figures (Acta Cytol 2003;47:1103)
Positive Stains
Molecular / Cytogenetics Description
Differential Diagnosis