Soft tissue
Smooth muscle
Genital leiomyoma

Author: Vijay Shankar, M.D. (see Authors page)

Revised: 29 September 2016, last major update November 2012

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Genital leiomyoma

Cite this page: Genital leiomyoma. website. Accessed October 27th, 2016.
Definition / General
  • Solitary tumor, arises from smooth muscle (dartos) bundles in superficial subcutaneous tissue or related structures of genitalia (penis / scrotum, labia, anal skin) or areola / nipple
  • Also known as dartotic leiomyoma
Case Reports
Clinical Images

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Nipple tumor

Micro Description
  • Classic features of leiomyoma, but may also be cellular, epithelioid or myxoid
  • Suggested classification for vulvar tumors is based on number of features below (0 - 1: leiomyoma, 2: atypical leiomyoma, 3 - 4: leiomyosarcoma)
    • 5+ cm in greatest dimension
    • Infiltrative margins
    • 5+ mitotic figures per 10 hpf
    • Moderate to severe cytologic atypia (Am J Surg Pathol 1996;20:779)
Micro Images

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Nipple tumor: H&E, desmin

Scrotal biopsy

Positive Stains