Soft tissue
Smooth muscle
Genital leiomyoma

Topic Completed: 1 November 2012

Revised: 26 March 2019

Copyright: 2002-2018,, Inc.

PubMed Search: Genital leiomyoma

Vijay Shankar, M.D.
Page views in 2018: 373
Page views in 2019 to date: 454
Cite this page: Shankar V. Genital leiomyoma. website. Accessed October 18th, 2019.
Definition / general
  • Solitary tumor, arises from smooth muscle (dartos) bundles in superficial subcutaneous tissue or related structures of genitalia (penis / scrotum, labia, anal skin) or areola / nipple
  • Also known as dartotic leiomyoma
Case reports
Clinical images

Images hosted on other servers:

Nipple tumor

Microscopic (histologic) description
  • Classic features of leiomyoma, but may also be cellular, epithelioid or myxoid
  • Suggested classification for vulvar tumors is based on number of features below (0 - 1: leiomyoma, 2: atypical leiomyoma, 3 - 4: leiomyosarcoma)
    • 5+ cm in greatest dimension
    • Infiltrative margins
    • 5+ mitotic figures per 10 hpf
    • Moderate to severe cytologic atypia (Am J Surg Pathol 1996;20:779)
Microscopic (histologic) images

Images hosted on other servers:

Nipple tumor: H&E, desmin

Scrotal biopsy

Positive stains
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