Soft Tissue
Skeletal muscle
Genital type rhabdomyoma

Author: Vijay Shankar, M.D. (see Authors page)

Revised: 3 November 2015, last major update November 2012

Copyright: (c) 2003-2015,, Inc.

PubMed Search: Genital [title] rhabdomyoma
Definition / General
  • Rare benign tumor with skeletal muscle differentiation in vagina, vulva or cervix, usually in middle aged women and rarely urethra
  • Extracardiac rhabdomyomas are divided into adult, fetal, and genital (below) histologic types
  • Extracardiac tumors are not associated with tuberous sclerosis
  • Rarely occurs in males in paratesticular region or epididymis or in the tunica vaginalis of the testis or prostate
  • Mean age 42 years
Case Reports
  • Local excision is curative
Gross Description
  • Well circumscribed, solitary, up to 3 cm
  • Resembles polyp
  • Covered by smooth mucosa
Micro Description
  • Submucosal, polypoid, well circumscribed, no capsule
  • Haphazard strap-like or round striated muscle fibers in fibrous stroma with dilated vessels
  • Cells have abundant eosinophilic cytoplasm with glycogen, cross striations, longitudinal myofibrils
  • Nucleus is round, vesicular, central and uniform
  • May have bi- or multinucleated cells
  • No / rare mitotic figures, no cambium layer, no spider cells, no spindle cells or rhabdomyoblasts, no necrosis, no nuclear pleomorphism
Micro Images
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Submucosal proliferation of haphazard skeletal muscle cells with prominent cross striations and fibromyxoid stroma

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Cervix, various images

Positive Stains
Negative Stains
Differential Diagnosis