Soft tissue tumors
Low / intermediate grade vascular tumors
Giant cell angioblastoma

Author: Vijay Shankar, M.D. (see Authors page)

Revised: 19 September 2016, last major update November 2012

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PubMed search: giant cell angioblastoma

Definition / General
Treatment
  • Surgery, interferon-alpha
Gross Description
  • Ulcerated tumors infiltrating soft tissue and bone
Micro Description
  • Solid, nodular, and plexiform proliferation of oval-spindle cells with striking concentric aggregation around small vascular channels
  • Cells resemble undifferentiated mesenchymal cells, fibroblasts, myofibroblasts, pericytes
  • Also large mononuclear and multinucleate giant cells with histiocytic features (Am J Surg Pathol 2001;25:185)
Micro Images
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Femur

Stains

Positive Stains
  • CD68 (large mononuclear and multinucleate giant cells)
Differential Diagnosis