Soft tissue tumors
Low / intermediate grade vascular tumors
Giant cell angioblastoma

Author: Vijay Shankar, M.D.

Revised: 31 January 2018, last major update November 2012

Copyright: (c) 2002-2018,, Inc.

PubMed search: Giant cell angioblastoma

Cite this page: Shankar, V. Giant cell angioblastoma. website. Accessed March 21st, 2018.
Definition / general
  • Surgery, interferon-alpha
Gross description
  • Ulcerated tumors infiltrating soft tissue and bone
Microscopic (histologic) description
  • Solid, nodular, and plexiform proliferation of oval-spindle cells with striking concentric aggregation around small vascular channels
  • Cells resemble undifferentiated mesenchymal cells, fibroblasts, myofibroblasts, pericytes
  • Also large mononuclear and multinucleate giant cells with histiocytic features (Am J Surg Pathol 2001;25:185)
Microscopic (histologic) images
Images hosted on other servers:



Positive stains
  • CD68 (large mononuclear and multinucleate giant cells)
Differential diagnosis