Soft tissue tumors
Low / intermediate grade vascular tumors
Giant cell angioblastoma

Author: Vijay Shankar, M.D.

Revised: 31 January 2018, last major update November 2012

Copyright: (c) 2002-2018,, Inc.

PubMed search: Giant cell angioblastoma

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Cite this page: Shankar, V. Giant cell angioblastoma. website. Accessed February 16th, 2019.
Definition / general
  • Surgery, interferon-alpha
Gross description
  • Ulcerated tumors infiltrating soft tissue and bone
Microscopic (histologic) description
  • Solid, nodular, and plexiform proliferation of oval-spindle cells with striking concentric aggregation around small vascular channels
  • Cells resemble undifferentiated mesenchymal cells, fibroblasts, myofibroblasts, pericytes
  • Also large mononuclear and multinucleate giant cells with histiocytic features (Am J Surg Pathol 2001;25:185)
Microscopic (histologic) images
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Positive stains
  • CD68 (large mononuclear and multinucleate giant cells)
Differential diagnosis