Soft tissue tumors
Low / intermediate grade vascular tumors
Giant cell angioblastoma



Topic Completed: 1 November 2012

Revised: 27 March 2019

Copyright: 2002-2018, PathologyOutlines.com, Inc.

PubMed search: Giant cell angioblastoma

Vijay Shankar, M.D.
Page views in 2018: 657
Page views in 2019 to date: 492
Cite this page: Shankar V. Giant cell angioblastoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/softtissuegiantcellangio.html. Accessed August 21st, 2019.
Definition / general
Treatment
  • Surgery, interferon-alpha
Gross description
  • Ulcerated tumors infiltrating soft tissue and bone
Microscopic (histologic) description
  • Solid, nodular, and plexiform proliferation of oval-spindle cells with striking concentric aggregation around small vascular channels
  • Cells resemble undifferentiated mesenchymal cells, fibroblasts, myofibroblasts, pericytes
  • Also large mononuclear and multinucleate giant cells with histiocytic features (Am J Surg Pathol 2001;25:185)
Microscopic (histologic) images
Images hosted on other servers:

Femur

Stains

Positive stains
  • CD68 (large mononuclear and multinucleate giant cells)
Differential diagnosis
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