Soft tissue tumors - Granular cell tumor

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Soft tissue tumors
Other tumors
Granular cell tumor

Reviewer: Vijay Shankar, M.D. (see Reviewers page)
Revised: 10 March 2013, last major update November 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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Classic location is tongue, also most other tissues
Blacks may have multiple lesions
Congenital tumors occur in gingiva, but are rare; occasionally congenital tumors are systemic
Usually benign, although malignant tumors also look benign; those that appear malignant may be alveolar soft part sarcoma
May reflect degenerative change that can occur in Schwann cells, smooth muscle cells or tumors

Case reports
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26 year old man with tongue nodule (J Med Case Rep 2012;6:56)
40 year old man with forearm lesion (Indian J Dermatol 2012;57:330)
53 year old woman with orbital tumor (Arq Bras Oftalmol 2012;75:137)
59 year old woman with chest wall mass (Korean J Thorac Cardiovasc Surg 2012;45:196)

Gross description
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Hard, ill defined margins, usually < 5 cm, may be ulcerated, may appear malignant

Gross / clinical images
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Chest wall

Tongue nodule

Forearm

Micro description
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Large cells with highly granular cytoplasm, small regular granules plus larger eosinophilic PAS+ round droplets
Associated with secondary epithelial hyperplasia (pseudoepitheliomatous hyperplasia) when grow near an epithelial surface
May see stromal elastosis

Micro images
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Various images

Erythematous lesion on forearm

Orbit

Chest wall

Tongue nodule

Scrotum

Cytology images
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**Forearm**

Positive stains
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S100 (nuclear and cytoplasmic), acid phosphatase, luxol fast blue, PAS

Electron microscopy description
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Granules resemble lysosomes, also angulated bodies with Gaucher cell-like appearance, replicated basal lamina around granular cells

End of Soft tissue tumors > Other tumors > Granular cell tumor

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