Soft tissue
Other tumors
Granular cell tumor

Author: Vijay Shankar, M.D. (see Authors page)

Revised: 15 September 2016, last major update November 2012

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed search: granular cell tumor [title] soft tissue

Definition / General
  • Classic location is tongue, also most other tissues
  • Blacks may have multiple lesions
  • Congenital tumors occur in gingiva, but are rare; occasionally congenital tumors are systemic
  • Usually benign, although malignant tumors also look benign; those that appear malignant may be alveolar soft part sarcoma
  • May reflect degenerative change that can occur in Schwann cells, smooth muscle cells or tumors
Case Reports
Clinical Images
Images hosted on PathOut server:

Arm, courtesy of Dr. Mark R. Wick



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Tongue nodule

Forearm

Gross Description
  • Hard, ill defined margins, usually < 5 cm, may be ulcerated, may appear malignant
Gross Images
Images hosted on PathOut server:

Courtesy of Dr. Mark R. Wick



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Chest wall

Micro Description
  • Large cells with highly granular cytoplasm, small regular granules plus larger eosinophilic PAS+ round droplets
  • Associated with secondary epithelial hyperplasia (pseudoepitheliomatous hyperplasia) when grow near an epithelial surface
  • May see stromal elastosis
Micro Images
Images hosted on PathOut server:

Courtesy of Dr. Mark R. Wick



Images hosted on other servers:

Various images

Erythematous lesion on forearm

Chest wall

Tongue nodule


Scrotum

Cytology Images
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Forearm

Positive Stains
Electron Microscopy Description
  • Granules resemble lysosomes, also angulated bodies with Gaucher cell-like appearance, replicated basal lamina around granular cells