Soft tissue
Low / intermediate grade vascular tumors
Spindle cell hemangioendothelioma

Author: Vijay Shankar, M.D.

Revised: 31 January 2018, last major update November 2012

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed search: "Spindle cell" hemangioendothelioma [title]

Related topics: Hemangioendothelioma

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Cite this page: Shankar, V. Spindle cell hemangioendothelioma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/softtissuehemangioendotheliomaspindle.html. Accessed June 20th, 2019.
Definition / general
  • Any age, usually males, usually distal extremities
  • Low grade lesion which recurs commonly and may be multicentric, but only one reported metastases after repeated recurrence and radiation therapy
  • May be a hamartoma due to aberrations in local blood blow; perhaps should be called spindle cell hemangioma
  • Associated with Mafucci's syndrome
Case reports
Clinical images
Images hosted on other servers:

Intramuscular tumor of temporal region

Gross description
  • Dermal or subcutaneous tumor
Microscopic (histologic) description
  • Cavernous hemangioma and Kaposi sarcoma like features
  • Cavernous spaces with solid areas composed predominantly of bland spindle cells, with a minor component of epithelioid, often vacuolated, endothelial cells, usually associated with irregular fascicles of smooth muscle fibers and adjacent malformed vessels
Microscopic (histologic) images
Images hosted on other servers:

Intramuscular tumor of temporal region

Various images

Positive stains
  • Endothelial markers
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