Soft tissue
Fibroblastic / myofibroblastic tumors
Inclusion body fibromatosis

Author: Komal Arora, M.D. (see Authors page)

Revised: 24 August 2016, last major update July 2012

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Inclusion body fibromatosis

Cite this page: Inclusion body fibromatosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/softtissueinfantiledigitalfibromatosis.html. Accessed December 8th, 2016.
Definition / General
  • Dermal fibroblastic and myofibroblastic lesion with cytoplasmic eosinophilic inclusions, usually in digits of infants
  • Also called infantile digital fibromatosis, infantile digital fibroma (J Hand Surg Am 1995;20:1014)
  • Distinct lesion from classic fibromatosis (Am J Surg Pathol 2009;33:1)
Sites
Clinical Features
  • Rare; lesions usually present at birth or in first 2 years
  • Similar lesions in adults
  • Often are multiple
Case Reports
Treatment
Clinical Images

Images hosted on PathOut servers:

Courtesy of Mark R. Wick, M.D.



Images hosted on other servers:

Various images

Gross Description
  • Nodules with stretched overlying skin, lesions are ill defined, white-tan, usually 2 cm or less
  • No hemorrhage or necrosis
Micro Description
  • Nonencapsulated, dermal proliferation of hypocellular sheets or fascicles of fibroblasts and myofibroblasts with variable collagen
  • Some spindle cells have peculiar eosinophilic (hyaline) cytoplasmic inclusions the size of a lymphocyte nucleus
  • Usually mitotic figures
  • May infiltrate into adjacent tissue
  • No atypia
Micro Images

Images hosted on PathOut servers:

Proliferation extends from epidermis to deep dermis/subcutis

Fibroblastic cells swirl around and engulf an eccrine duct

Cells are bland and monomorphic

Inclusions resemble red blood cells



Cytoplasim inclusions, courtesy of Mark R. Wick, M.D.

Courtesy of Mark R. Wick, M.D.



Images hosted on other servers:

Various images

Cytology Description
Positive Stains
Negative Stains
Electron Microscopy Description
  • Spindle cells are myofibroblasts with rough endoplasmic reticulum and free lying inclusions composed of compact masses of actin granules and filaments without a limiting membrane (Am J Pathol 1979;94:19)
Differential Diagnosis
Additional References