Home Chapter Home Jobs Conferences Fellowships Books
Soft Tissue Tumors
Inflammatory liposarcoma - subtype of atypical lipomatous tumor /
well differentiated liposarcoma
Author: Nat Pernick, M.D., PathologyOutlines.com, Inc.
Reviewer: David Lucas, M.D., University of Michigan Health Systems (January 2009)
Revised: 26 June 2009, last major update June 2009
Definition
=========================================================================
● Nodular aggregates of chronic inflammatory cells with scattered large atypical cells
● Paucicellular stroma with fibroblastic cells
● Remaining lesion is typical well differentiated liposarcoma (AJSP 1997;21:518)
● Not a WHO diagnosis
Epidemiology
=========================================================================
● Rare variant with similar clinical presentation to classic type (AJSP 1997;21:884)
Case reports
=========================================================================
● 37 year old man with 35 cm abdomino-pelvic mass (Indian J Cancer 2006;43:36)
● 79 year old woman with thigh mass (Archives 2004;128:e21)
Gross images
=========================================================================
Retroperitoneal tumor 35 cm tumor weighing 9 kg
Micro description
=========================================================================
● Prominent chronic inflammation that resembles lymphoma and may obscure sarcomatous component
Micro images
=========================================================================
Inflammatory variant Highly pleomorphic tumor cells surrounded by neutrophils
Fig 1: tan-white, firm, fibrous lobule, Fig 2: inflammatory cells separated by broad bands of fibrous tissue,
Fig 3: large atypical cells with hyperchromatic and lobated pleomorphic nuclei, Fig 4: rare lipoblasts
Focal dense inflammatory infiltrate
Cytology description
=========================================================================
● Numerous dispersed lymphocytes and plasma cells
● Scattered large atypical cells with abundant ill defined cytoplasm, multiple or hyperlobated nuclei and coarse chromatin
● Also fibrous tissue fragments containing both types of cells (Diagn Cytopathol 1999;20:229)
Differential diagnosis
=========================================================================
● Hodgkin’s lymphoma - no well differentiated liposarcoma component, no lipoblasts, negative for MDM2, CDK4, 12q13-15 rearrangement
● Inflammatory pseudotumor - no well differentiated liposarcoma component, no lipoblasts, negative for MDM2, CDK4, 12q13-15 rearrangement (AJSP 1997;21:518)
● MFH-inflammatory - no well differentiated liposarcoma component, no lipoblasts, negative for MDM2, CDK4, 12q13-15 rearrangement
● Sclerosing mesenteritis or idiopathic retroperitoneal fibrosis - no well differentiated liposarcoma component, no lipoblasts, negative for MDM2, CDK4, 12q13-15 rearrangement (Mod Pathol 2009;22:66)
End of Soft Tissue Tumors > Inflammatory liposarcoma
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must also be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.
All information on this website is protected by Copyright, (c) 2001-2009, PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions.