Soft tissue
Smooth muscle
Classic leiomyoma

Author: Vijay Shankar, M.D. (see Authors page)

Revised: 29 September 2016, last major update November 2012

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Classic leiomyoma

Cite this page: Classic leiomyoma. website. Accessed October 24th, 2016.
Definition / General
  • Bland smooth muscle tumor without mitotic figures (eMedicine)
  • Not a WHO diagnosis (cutaneous and pilar tumors are described in the Skin volume)
  • Some tumors previously considered to be leiomyomas are actually GI stromal (GIST) tumors
  • See also colon-tumor, esophagus, uterus chapters
  • Skin and subcutis; also deep soft tissue, uterus (most common neoplasm in women)
  • Patients with multiple cutaneous leiomyomas may have autosomal dominant disorder (described under Cutaneous leiomyoma)
Case Reports
Gross Images

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Myxoid subcutaneous tumor

Micro Description
  • Bundles or fascicles of spindled cells with eosinophilic and possibly fibrillary cytoplasm
  • Nuclei are blunt ended and elongated with fine chromatin, indistinct nucleolus and variable cytoplasmic vacuole at one end
  • Minimal atypia
  • Few mitotic figures
  • No coagulative tumor necrosis
Micro Images

Images hosted on PathOut servers:

Oblong nuclei have rounded ends

Bundles of elongate
cells with eosinophilic
cytoplasm and oblong nuclei

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Calcified leiomyoma

Negative Stains
Differential Diagnosis
  • Angiomyolipoma: usually prominent vascular and lipomatous component
  • Leiomyosarcoma: more cellular, infiltrative, pleomorphic; mitotic activity and coagulative tumor cell necrosis