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Smooth muscle
Leiomyoma of deep soft tissue


Vijay Shankar, M.D.

Topic Completed: 1 November 2012

Revised: 26 December 2019

Copyright: 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Leiomyoma of deep soft tissue

Vijay Shankar, M.D.
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Table of Contents
Definition / general | Epidemiology | Case reports | Treatment | Clinical images | Gross description | Microscopic (histologic) description | Cytology description | Positive stains | Negative stains | Differential diagnosis
Cite this page: Shankar V. Leiomyoma of deep soft tissue. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/softtissueleiomyomadeep.html. Accessed February 23rd, 2020.
Definition / general
  • Very rare tumor of deep subcutis or skeletal muscle of extremities (Stanford University) or retroperitoneum (described below)
  • By definition, is distinct from uterus
Epidemiology
  • Tumors of deep somatic soft tissue affect males and females equally (Am J Surg Pathol 2001;25:1134)
  • Tumors of retroperitoneum (described below) almost always occur in women
  • Can rarely occur in children
Case reports
Treatment
  • Excision; rarely recurs
Clinical images

Images hosted on other servers:

Hand mass:
intraoperative and
gross specimen

Gross description
  • Well circumscribed, gray-white
  • Usually large at presentation, up to 15 cm
  • May have myxoid change
Microscopic (histologic) description
  • Fascicles of normal appearing smooth muscle with eosinophilic cytoplasm
  • Nuclei are bland and uniform, blunt ended, cigar shaped
  • May have dystrophic calcification, degenerative nuclear changes or necrobiotic nodules resembling giant rosettes
  • Hyalinization and fatty differentiation can also be seen rarely
  • No / minimal atypia
  • No / rare mitotic figures (Am J Surg Pathol 1994;18:576); < 1 per 50 HPF
  • No necrosis
Cytology description
  • Hypocellular smears, with scattered clusters of spindle cells (Diagn Cytopathol 1997;16:326)
  • Clustered cells have syncytial appearance
  • Bland nuclei have spindled appearance with rounded ends, condensed chromatin
  • Usually no necrosis or inflammation
  • No mitotic figures
Positive stains
Negative stains
Differential diagnosis
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