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Soft tissue
Fibroblastic / myofibroblastic tumors
Low-grade fibromyxoid sarcoma

Reviewer: Raul Gonzalez, M.D. (see Reviewers page)
Editor: Jerad M. Gardner, M.D.
Revised: 25 April 2013, last major update April 2013
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.

Definition
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Epidemiology
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Clinical features
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Prognostic factors
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Radiology
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Case reports
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Treatment
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Gross description
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Gross images
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Tumor of falciform ligament
Well- circumscribed tumor of leg
Well- circumscribed tumor with giant rosettes
Low-grade fibromyxoid sarcoma
Figure 5
Micro description
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Micro images
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AFIP:
Figure 1
Figure 2
Figure 3
Fig 1: characteristic features include fibrous and myxoid areas, a swirling whorled growth pattern, low to moderate cellularity and bland cells with minimal nuclear pleomorphism
Fig 2: the swirling growth pattern is storiform
Fig 3: there is a relatively linear cell arrangement in this area, but other areas have the characteristic swirling and whorled pattern


Other:
Figure 6
Figure 7
Figure 8
Myxoid area showing arcades of blood vessels
Storiform pattern
Bland spindle cells in fibromyxoid stroma
Rosettes in spindled stroma
Covered by pelvic urothelium
Alternating fibrous and myxoid areas
Cells forming rosettes are PGP 9.5+, Factor XIII negative
Staining of vessels but not tumor by CD34, smooth muscle actin
Vimentin+

Contributed by Mark Rodacker:
Various images
Cytology description
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Cytology images
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Figure 1
Figure 2
Figure 3
Figure 4
Virtual slides
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Low grade fibromyxoid sarcoma

LGFMS from Jerad M. Gardner, MD,
Virtual Soft Tissue Pathology Study Set
Positive stains
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Negative stains
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Electron microscopy description
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Electron microscopy images
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Rosette-forming cells have dense core granules
Figure 9
Molecular / cytogenetics description
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Molecular / cytogenetics images
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Complex karyotype includes t(7;16)
Differential diagnosis
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Additional references
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End of Soft tissue > Fibroblastic / myofibroblastic tumors > Low-grade fibromyxoid sarcoma


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