Home Chapter Home Jobs Conferences Fellowships Books
Soft Tissue Tumors
Lipoleiomyosarcoma - subtype of atypical lipomatous tumor / well differentiated liposarcoma
Author: Nat Pernick, M.D., PathologyOutlines.com, Inc.
Reviewer: David Lucas, M.D., University of Michigan Health Systems (January 2009)
Revised: 26 June 2009, last major update June 2009
Definition
=========================================================================
● Well-differentiated liposarcoma with a leiomyosarcoma component
● Not a WHO diagnosis
Epidemiology
=========================================================================
● Rare; may be a dual lineage sarcoma with multifocal smooth muscle component arising from atypical changes in vessel wall, and separate from atypical changes in fat (AJSP 2002;26:742)
Treatment and prognosis
=========================================================================
● Similar prognosis to conventional well differentiated liposarcoma
Case reports
=========================================================================
● 76 year old man with mediastinal tumor (Pathology 1997;29:428)
Micro description
=========================================================================
● Combined features of liposarcoma and leiomyosarcoma
● Well differentiated tumors are low grade
● May arise from or mix with smooth muscle in walls of large vessels within the tumor
Micro images
=========================================================================
Uterine tumor - Figure 1: fascicles of large spindle cells with atypical nuclei; figure 2: multinucleated giant cells and
atypical mitotic figure; figure 3: multivacuolated lipoblasts with large hyperchromatic nuclei; figure 4: caldesmon+
Differential diagnosis
=========================================================================
● Dedifferentiated liposarcoma - highly atypical smooth muscle or other types of sarcoma present
● Myolipoma - bland smooth muscle present; no lipoblasts, negative for MDM2, CDK4, 12q13-15 rearrangement
● Angiomyolipoma - smooth muscle has cytoplasmic clearing, no fibrous septae or hyperchromatic stromal cells, no lipoblasts; positive for melanoma markers, negative for MDM2, CDK4, 12q13-15 rearrangement
End of Soft Tissue Tumors > Lipoleiomyosarcoma - subtype of atypical lipomatous tumor /
well differentiated liposarcoma of soft tissue
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must also be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.
All information on this website is protected by Copyright, (c) 2001-2009, PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions.