Soft Tissue Tumors - Lipoleiomyosarcoma - subtype of atypical lipomatous tumor / well differentiated liposarcoma

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Soft Tissue Tumors

Adipose tissue

Lipoleiomyosarcoma - subtype of atypical lipomatous tumor / well differentiated liposarcoma

Reviewer: Charanjeet Singh, M.D. (see Reviewers page)
Revised: 13 November 2012, last major update June 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Well-differentiated liposarcoma with a leiomyosarcomatous component
● Not a WHO diagnosis

Epidemiology
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● Rare
● May be a dual lineage sarcoma with multifocal smooth muscle component arising from atypical changes in vessel wall, and separate from atypical changes in fat (Am J Surg Pathol 2002;26:742)

Treatment and prognosis
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● Similar prognosis to conventional well differentiated liposarcoma

Case reports
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● 76 year old man with mediastinal tumor (Pathology 1997;29:428)

Micro description
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● Combined features of liposarcoma and leiomyosarcoma
● Well differentiated tumors are low grade
● May arise from or mix with smooth muscle in walls of large vessels within the tumor

Micro images
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Uterine tumor: H&E and caldesmon

Differential diagnosis
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● Dedifferentiated liposarcoma: highly atypical smooth muscle or other types of sarcoma present
● Myolipoma: bland smooth muscle present; no lipoblasts, negative for MDM2, CDK4, no 12q13-15 rearrangement
● Angiomyolipoma: smooth muscle has cytoplasmic clearing, no fibrous septae or hyperchromatic stromal cells, no lipoblasts; positive for melanoma markers, negative for MDM2, CDK4, no 12q13-15 rearrangement

Additional references
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● Int J Gynecol Pathol 2012;31:358 (uterus), Head Neck 2012 Feb 6 [Epub ahead of print] (larynx)

End of Soft Tissue Tumors > Adipose tissue > Lipoleiomyosarcoma - subtype of atypical lipomatous tumor / well differentiated liposarcoma

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