Soft tissue
Adipose tissue
Lipoleiomyosarcoma - subtype of atypical lipomatous tumor / well differentiated liposarcoma

Author: Charanjeet Singh, M.D. (see Authors page)

Revised: 10 August 2016, last major update June 2012

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Lipoleiomyosarcoma

Cite this page: Lipoleiomyosarcoma. website. Accessed October 23rd, 2016.
Definition / General
  • Well-differentiated liposarcoma with a leiomyosarcomatous component
  • Not a WHO diagnosis
  • Rare
  • May be a dual lineage sarcoma with multifocal smooth muscle component arising from atypical changes in vessel wall, and separate from atypical changes in fat (Am J Surg Pathol 2002;26:742)
Case Reports
  • Similar prognosis to conventional well differentiated liposarcoma
Micro Description
  • Combined features of liposarcoma and leiomyosarcoma
  • Well differentiated tumors are low grade
  • May arise from or mix with smooth muscle in walls of large vessels within the tumor
Micro Images

Images hosted on other servers:

Uterine tumor: H&E and caldesmon

Differential Diagnosis
  • Angiomyolipoma: smooth muscle has cytoplasmic clearing, no fibrous septae or hyperchromatic stromal cells, no lipoblasts; positive for melanoma markers, negative for MDM2, CDK4, no 12q13-15 rearrangement
  • Dedifferentiated liposarcoma: highly atypical smooth muscle or other types of sarcoma present
  • Myolipoma: bland smooth muscle present; no lipoblasts, negative for MDM2, CDK4, no 12q13-15 rearrangement