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Soft Tissue Tumors
Lipoleiomyosarcoma - subtype of atypical lipomatous tumor / well differentiated liposarcoma
Reviewer: Charanjeet Singh, M.D. (see Reviewers page)
Revised: 13 November 2012, last major update June 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.
● Well-differentiated liposarcoma with a leiomyosarcomatous component
● Not a WHO diagnosis
● May be a dual lineage sarcoma with multifocal smooth muscle component arising from atypical changes in vessel wall, and separate from atypical changes in fat (Am J Surg Pathol 2002;26:742)
Treatment and prognosis
● Similar prognosis to conventional well differentiated liposarcoma
● 76 year old man with mediastinal tumor (Pathology 1997;29:428)
● Combined features of liposarcoma and leiomyosarcoma
● Well differentiated tumors are low grade
● May arise from or mix with smooth muscle in walls of large vessels within the tumor
Uterine tumor: H&E and caldesmon
● Dedifferentiated liposarcoma: highly atypical smooth muscle or other types of sarcoma present
● Myolipoma: bland smooth muscle present; no lipoblasts, negative for MDM2, CDK4, no 12q13-15 rearrangement
● Angiomyolipoma: smooth muscle has cytoplasmic clearing, no fibrous septae or hyperchromatic stromal cells, no lipoblasts; positive for melanoma markers, negative for MDM2, CDK4, no 12q13-15 rearrangement
● Int J Gynecol Pathol 2012;31:358 (uterus), Head Neck 2012 Feb 6 [Epub ahead of print] (larynx)
End of Soft Tissue Tumors > Adipose tissue > Lipoleiomyosarcoma - subtype of atypical lipomatous tumor / well differentiated liposarcoma
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