Soft tissue
Lymphangioma
Lymphangiosarcoma

Author: Vijay Shankar, M.D.

Revised: 11 September 2018, last major update November 2012

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed search: Lymphangiosarcoma [title] soft tissue

Cite this page: Shankar, V. Lymphangiosarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/softtissuelymphangiosarcoma.html. Accessed December 12th, 2018.
Definition / general
  • Typically ~10 years post axillary nodal dissection or radiation therapy for breast cancer with long standing massive lymphedema
  • Also after chronic lymphedema of lower leg
  • 5 year survival < 10%
Case reports
Clinical images

Images hosted on other servers:

Neck plaque

Arm

Gross description
  • Blue / purple papules in edematous skin, often multiple
Microscopic (histologic) description
  • Angiosarcoma-like areas and endothelium lined spaces without red blood cells
  • Early: resembles benign collection of vessels, called "atypical vascular proliferation"
  • Later: freely anastomosing vascular channels lined by atypical endothelial cells, often with solid areas resembling breast carcinoma
  • Increased cellularity and pleomorphism with increased mitotic activity
Microscopic (histologic) images

Images hosted on PathOut server:

Contributed by Mark R. Wick, M.D.

Scalp



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Various images

Thin walled vascular channels lined by endothelial cells are CD31

Positive stains
Differential diagnosis