Soft tissue
Lymphangioma
Lymphangiosarcoma

Author: Vijay Shankar, M.D. (see Authors page)

Revised: 29 September 2016, last major update November 2012

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed search: lymphangiosarcoma [title] soft tissue

Cite this page: Lymphangiosarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/softtissuelymphangiosarcoma.html. Accessed December 9th, 2016.
Definition / General
  • Typically ~10 years post axillary nodal dissection or radiation therapy for breast cancer with long standing massive lymphedema
  • Also after chronic lymphedema of lower leg
  • 5 year survival < 10%
Case Reports
Clinical Images
Images hosted on other servers:

Neck plaque

Arm

Gross Description
  • Blue / purple papules in edematous skin, often multiple
Micro Description
  • Angiosarcoma-like areas and endothelium lined spaces without red blood cells
  • Early: resembles benign collection of vessels, called "atypical vascular proliferation"
  • Later: freely anastomosing vascular channels lined by atypical endothelial cells, often with solid areas resembling breast carcinoma
  • Increased cellularity and pleomorphism with increased mitotic activity
Micro Images
Images hosted on PathOut server:

Scalp, courtesy of of Dr. Mark R. Wick



Images hosted on other servers:

Various images

Thin walled vascular channels lined by endothelial cells are CD31

Positive Stains
Differential Diagnosis