Soft tissue

Author: Vijay Shankar, M.D. (see Authors page)

Revised: 29 September 2016, last major update November 2012

Copyright: (c) 2003-2016,, Inc.

PubMed search: lymphangiosarcoma [title] soft tissue

Cite this page: Lymphangiosarcoma. website. Accessed August 20th, 2018.
Definition / general
  • Typically ~10 years post axillary nodal dissection or radiation therapy for breast cancer with long standing massive lymphedema
  • Also after chronic lymphedema of lower leg
  • 5 year survival < 10%
Case reports
Clinical images
Images hosted on other servers:

Neck plaque


Gross description
  • Blue / purple papules in edematous skin, often multiple
Microscopic (histologic) description
  • Angiosarcoma-like areas and endothelium lined spaces without red blood cells
  • Early: resembles benign collection of vessels, called "atypical vascular proliferation"
  • Later: freely anastomosing vascular channels lined by atypical endothelial cells, often with solid areas resembling breast carcinoma
  • Increased cellularity and pleomorphism with increased mitotic activity
Microscopic (histologic) images
Images hosted on PathOut server:

Scalp, courtesy of of Dr. Mark R. Wick

Images hosted on other servers:

Various images

Thin walled vascular channels lined by endothelial cells are CD31

Positive stains
Differential diagnosis