Table of ContentsDefinition / general | Case reports | Clinical images | Gross description | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Differential diagnosis
Cite this page: Shankar, V. Lymphangiosarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/softtissuelymphangiosarcoma.html. Accessed February 16th, 2019.
Definition / general
- Typically ~10 years post axillary nodal dissection or radiation therapy for breast cancer with long standing massive lymphedema
- Also after chronic lymphedema of lower leg
- 5 year survival < 10%
- Blue / purple papules in edematous skin, often multiple
Microscopic (histologic) description
- Angiosarcoma-like areas and endothelium lined spaces without red blood cells
- Early: resembles benign collection of vessels, called "atypical vascular proliferation"
- Later: freely anastomosing vascular channels lined by atypical endothelial cells, often with solid areas resembling breast carcinoma
- Increased cellularity and pleomorphism with increased mitotic activity
Microscopic (histologic) images