Soft tissue
Fibrohistiocytic tumors
Malignant giant cell tumor of tendon sheath - diffuse type

Author: Vijay Shankar, M.D.

Revised: 30 January 2018, last major update August 2012

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Malignant giant cell tumor of tendon sheath - diffuse type

See also: Giant cell tumor of tendon sheath - diffuse type

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Cite this page: Shankar, V. Malignant giant cell tumor of tendon sheath - diffuse type. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/softtissuemalignantgctdiffuse.html. Accessed November 12th, 2019.
Definition / general
  • Rare tumor with coexisting or prior benign giant cell tumor plus sarcomatous areas
  • Not a WHO diagnosis
Clinical features
Case reports
Gross description
  • Mean 9 cm
Microscopic (histologic) description
  • Benign areas with gradual or abrupt change to frank sarcoma containing pleomorphic, spindle or enlarged oval cells resembling MFH, fibrosarcoma, myxosarcoma or giant cell tumor with large nuclei and prominent nucleoli (Am J Surg Pathol 1997;21:153)
  • Also necrosis and atypical mitotic figures
  • Higher Ki-67 index
Molecular / cytogenetics description
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