Soft tissue
Uncertain differentiation
Myoepithelioma / Myoepithelial carcinoma / Mixed tumor


Topic Completed: 1 November 2012

Revised: 5 September 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed search: Myoepithelial carcinoma of soft tissue

Vijay Shankar, M.D.
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Cite this page: Shankar V. Myoepithelioma / Myoepithelial carcinoma / Mixed tumor. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/softtissuemyoepithelialca.html. Accessed September 22nd, 2019.
Definition / general
  • Rare tumor with myoepithelial elements but no ductal differentiation
  • Also called myoepithelioma, ectomesenchymal chondromyxoid tumor, parachordoma
Epidemiology
  • Equal gender frequency, occurs in all ages, but mean age 38 years
  • 20% occur in children, has an aggressive clinical course
Sites
  • Extremities, limb girdles, viscera, head & neck
Prognostic factors
Treatment and prognosis:

Case reports
Gross description
  • Mean 5 cm, often well circumscribed
Microscopic (histologic) description
  • Nests, cords and sheets of epithelioid, clear, spindle or plasmacytoid cells in hyalinized or chondromyxoid stroma
  • Epithelioid cells predominate in 93% of childhood cases
  • Moderate to severe atypia due to coarse chromatin, prominent nucleoli, nuclear pleomorphism
  • Variable mitotic rate (median 8 / 10 HPF)
  • Often tumor necrosis
Microscopic (histologic) images

Images hosted on other servers:

Various images

p63

Soft tissue malignant
myoepithelial
carcinomas -
characteristics

Positive stains
Molecular / cytogenetics description
Molecular / cytogenetics images

Images hosted on other servers:

FISH

Differential diagnosis
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