Soft tissue
Other tumors
Myoepithelial carcinoma of soft tissue

Author: Vijay Shankar, M.D.

Revised: 31 January 2018, last major update November 2012

Copyright: (c) 2002-2018,, Inc.

PubMed search: Myoepithelial carcinoma of soft tissue

Cite this page: Shankar, V. Myoepithelial carcinoma of soft tissue. website. Accessed March 21st, 2018.
Definition / general
  • Rare tumor with myoepithelial elements but no ductal differentiation
  • May be related to parachordoma or mixed tumor
  • Equal gender frequency, occurs in all ages, but mean age 38 years
  • 20% occur in children, has an aggressive clinical course
  • Extremities, limb girdles, viscera, head & neck
Prognostic factors
Treatment and prognosis:

Case reports
Gross description
  • Mean 5 cm, often well circumscribed
Microscopic (histologic) description
  • Nests, cords and sheets of epithelioid, clear, spindle or plasmacytoid cells in hyalinized or chondromyxoid stroma
  • Epithelioid cells predominate in 93% of childhood cases
  • Moderate to severe atypia due to coarse chromatin, prominent nucleoli, nuclear pleomorphism
  • Variable mitotic rate (median 8 / 10 HPF)
  • Often tumor necrosis
Microscopic (histologic) images

Various images


Soft tissue malignant
carcinomas -
Positive stains
Molecular / cytogenetics description
Molecular / cytogenetics images


Differential diagnosis