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Soft tissue
Fibroblastic / myofibroblastic tumors
Myofibroma / myofibromatosis

Reviewer: Deepti Reddi, M.D. (see Reviewers page)
Editor: Jerad M. Gardner, M.D.
Revised: 26 April 2013, last major update April 2013
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.

Definition
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Terminology
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Epidemiology
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Sites
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Etiology
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Clinical features
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Radiology
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Prognostic factors
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Case reports
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Treatment
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Gross description
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Micro description
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Micro images
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AFIP:
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Fig 1: Solitary cutaneous lesion features zones of fibrous tissue with bundles of myofibroblasts and prominent thin-walled vessels
Fig 2: High power shows interface with normal collagen
Fig 3: Biphasic with immature cells in hemangiopericytoma pattern and bundles of myofibroblastic cells
Fig 4: Central hemangiopericytic area is rimmed by hyalinized myofibroblastic area
Fig 5: Junction between myofibroblastic cells and immature spindled cells
Fig 6: Myofibroblastic spindle cells and immature cells are arranged in hemangiopericytic pattern

Other:
Infant lesion, arm tumor
Poorly circumscribed nodular tumor
Well circumscribed tumor
Fascicles of spindle cells resemble leiomyoma
Cellular and keloid-like areas #1
Cellular and keloid-like areas #2
Cellular and keloid-like areas #3
Cellular and keloid-like areas #4
Intracranial tumor
Various images
Dermis is infiltrated by fascicles of smooth muscle-like cells

Trichrome stain (fig B) highlights prominent
collagen not seen on H&E (fig A)

48 year old woman with nodules on scalp:
Myofibroblasts around capillaries and sclerosing areas
Tumor infiltrates skeletal muscle
Hemangio-pericytoma-like vascular pattern
Fascicles of myofibroblastic cells with oval nuclei
Smooth muscle actin+
Tumor is CD34-, desmin-; vessels are CD34+ desmin+
Virtual slides
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Myofibroma (from Jerad M. Gardner, MD - Virtual Soft Tissue Pathology Study Set)
Positive stains
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Negative stains
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Electron microscopy description
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Differential diagnosis
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End of Soft tissue > Fibroblastic / myofibroblastic tumors > Myofibroma / myofibromatosis


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