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Soft tissue tumors

Normal / benign

Myopericytoma


Reviewer: Vijay Shankar, M.D. (see Reviewers page)
Revised: 25 February 2013, last major update November 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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● Also called perivascular myoid tumor
● Usually adults, 60% male, median age 52 years, youngest case was age 10
● Affects skin (dermis or subcutis) or soft tissues of extremities, rarely head or trunk

Case reports
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● 32 year old woman with multiple lesions of face and parotid gland (Arch Plast Surg 2012;39:158)
● 45 year old woman with painless nodule on leg (Ann Dermatol 2011;23:201)
● 59 year old man with painless mass on nose (Acta Derm Venereol 2010;90:192)

Treatment
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● Excision; only rarely recurs

Gross / clinical images
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Multiple facial masses

Lower leg

Dorsal nose

Micro description
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● Thin walled vessels and concentric, perivascular arrangement of plump spindle to round myoxid cells
● May have hemangiopericytoma-like areas
● Occasional prominent atypia and mitotic activity
● Rarely infiltrative
● No giant cells (Am J Surg Pathol 2006;30:104)
● Rarely has lipomatous component (Cir Esp 2012;90:331)

Micro images
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Oval cells with eosinophilic cytoplasm

Well circumscribed spindle cell tumor

(a) Unencapsulated neoplasm in deep dermis extends into subcutis (arrows); (b) bland round-ovoid cells with concentric perivascular pattern and many thin-walled branching staghorn vessels

Lung tumor: 3A-SMA; 3B-vimentin, 3C-CD34

Positive stains
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● Alpha smooth muscle actin, h-caldesmon
● Rarely focal desmin

Differential diagnosis
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Angioleiomyoma
Myofibroma

End of Soft tissue tumors > Normal / benign > Myopericytoma


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