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Soft tissue
Fibroblastic / myofibroblastic tumors
Myxofibrosarcoma

Reviewer: Annie S. Morrison, M.D. (see Reviewers page)
Editor: Jerad M. Gardner, M.D.
Revised: 19 October 2013, last major update April 2013
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.

Definition
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Epidemiology
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Clinical features
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Prognostic factors
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Case reports
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Treatment
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Gross description
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Gross images
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Thigh tumor
Lower extremity tumor
Subcutaneous tumor
Micro description
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Grading: Micro images
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AFIP:
Myxoid areas may have pleomorphic cells and variable cellularity
Moderate cellularity with pleomorphic cells
Typical cellular areas with occasional giant cells
Grade I tumor has the minimal pleomorphism required for diagnosis
Grade II tumor: myxoid areas alternate with solid area that is not as pleomorphic as usual undifferentiated pleomorphic sarcoma

Grade III tumor with markedly
pleomorphic areas (left) and
myxoid areas (right), myxoid
areas may lack pleomorphic cells

Resembling ischemic or proliferative fasciitis:     Not myxofibrosarcoma due to lack of pleomorphism:
Myxoid stroma with low density of ganglion-like cells
Bizarre cells are strongly suggestive of malignancy, not a reactive condition
             
These lesions are called juxta-articular myxoma, cellular intramuscular myxoma or myxoid lesion with recurrent potential, they may recur but do not metastasize (controversial lesions)
Typical histology
Spindle-shaped cells
Metastatic lesion of clavicle
Myxoid nodules and fibrous septa
Spindle-shaped cells
Lipoblast-like cells
Curvilinear capillaries

Cytology description
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Positive stains
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Negative stains
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Electron microscopy description
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Electron microscopy images
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Maxillary sinus tumor
Molecular / cytogenetics description
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Differential diagnosis
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End of Soft tissue > Fibroblastic / myofibroblastic tumors > Myxofibrosarcoma


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