Soft tissue
Other tumors
Intramuscular myxoma

Author: Vijay Shankar, M.D.

Revised: 30 January 2018, last major update November 2012

Copyright: (c) 2002-2018,, Inc.

PubMed search: intramuscular myxoma [title] soft tissue

Related topics: Myxoma

Page views in 2018: 1,879
Page views in 2019 to date: 1,559
Cite this page: Shankar, V. Intramuscular myxoma. website. Accessed August 21st, 2019.
Definition / general
  • Painless, slow growing mass within large muscle groups of thigh, shoulder, pelvis
  • Usually women 40 - 60
  • Cell of origin may be fibroblast incapable of producing mature collagen that produces mucopolysaccharides instead
Case reports
Gross images
Images hosted on other servers:

Intramuscular myxoma

Intramuscular grey gleaming tumor

Gluteal tumor

Microscopic (histologic) description
  • Stellate or spindle cells with poorly defined cytoplasm, myxoid stroma; minimal pleomorphism or mitotic activity
Microscopic (histologic) images
Images hosted on PathOut server:

Courtesy of Dr. Mark R. Wick

Images hosted on other servers:

Various images

Molecular / cytogenetics description
Differential diagnosis
  • Chondrosarcoma: bone or soft tissue tumor that resembles chordoma with rows of cuboidal cells separated by myxoid background; S100+, vimentin+, keratin-
  • Liposarcoma: commonly in thigh / lower extremities; few mitotic figures but see lipoblasts, matrix contains lipopolysaccharides and matrix; prominent vascular component; t(12;1)(q13;p11)
  • Myxoid leiomyosarcoma: rare; gelatinous, well circumscribed; invasive, highly myxomatous; see typical smooth muscle cells alternating with mesenchymal cells
  • Myxoid MFH
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