Soft tissue
Peripheral nerve
Myxopapillary ependymoma

Author: Vijay Shankar, M.D. (see Authors page)

Revised: 21 September 2016, last major update November 2012

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Myxopapillary ependymoma [title]

Definition / General
  • Usually spinal cord tumor, may arise is soft tissue in sacrococcygeal area separate from cord
  • Resembles pilonidal cyst clinically, but 20% metastasize
Case Reports
Gross Description
  • Well circumscribed, easily enucleated
Gross Images

Images hosted on other servers:

Two ovoid mass

Micro Description
  • Resembles CNS tumor
  • Small blue cells forming well defined perivascular structures, surrounded by dense fibrous tissue
Micro Images

Images hosted on other servers:

Epithelioid cells with some cytoplasmic clearing

Cribriform pattern

Solid sheets and cords



L: S100; R: GFAP

L: AE1AE3; R: CAM5.2

Columnar cells

Radial processes

Positive Stains
Differential Diagnosis
  • Ependymal rests: clusters of cells < 0.5 cm in dermis / subcutaneous tissue near pilonidal sinuses