• Composed of axons, Schwann cells, perineurial cells and fibroblasts in epineurium (outer sheath)
• Perineurium: surrounds each nerve fascicle, is continuous with pia mater of CNS
• Perineurial cells: derived from fibroblasts; EMA+, S100-
• Schwann cells: neuroectodermally derived cells that resemble fibroblasts, but strongly S100+, intimately related to axons (by EM), have continuous basal lamina that coats the cell facing the endoneurium

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