Soft tissue
Peripheral nerve
Nerve sheath myxoma

Author: Vijay Shankar, M.D. (see Authors page)

Revised: 21 September 2016, last major update November 2012

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Nerve sheath myxoma [title]

Cite this page: Nerve sheath myxoma. website. Accessed December 17th, 2017.
Definition / general
  • Controversial tumor due to disputed relationship with neurothekeoma
  • Skin, soft tissue, intraspinal
  • Resembles myxoma but plumper, epithelial-like cells; fascicular or plexiform arrangement
  • Based on the amount of myxoid stroma, nerve sheath myxoma is divided into myxoid (classical), mixed and cellular types
Case reports
Clinical images

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Tender, solitary firm papule

Microscopic (histologic) description

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Cutaneous, courtesy of Mark R. Wick, M.D.

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Lower leg lesion

Gingival lesion is well demarcated

Thick, short collagen bundles and focal myxoid areas



Positive stains
Differential diagnosis