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Soft tissue
Peripheral nerve
Nerve sheath myxoma
Copyright: 2002-2018, PathologyOutlines.com, Inc.
PubMed Search: Nerve sheath myxoma [title]
Peripheral nerve
Nerve sheath myxoma
Author: Vijay Shankar, M.D.
Topic Completed: 1 November 2012
Revised: 26 March 2019
Copyright: 2002-2018, PathologyOutlines.com, Inc.
PubMed Search: Nerve sheath myxoma [title]
Table of Contents
Definition / general | Case reports | Clinical images | Microscopic (histologic) description | Positive stains | Differential diagnosisCite this page: Shankar V. Nerve sheath myxoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/softtissuenervesheathmyxoma.html. Accessed June 18th, 2019.
Definition / general
- Controversial tumor due to disputed relationship with neurothekeoma
- Skin, soft tissue, intraspinal
- Resembles myxoma but plumper, epithelial-like cells; fascicular or plexiform arrangement
- Based on the amount of myxoid stroma, nerve sheath myxoma is divided into myxoid (classical), mixed and cellular types
Case reports
- 32 year old woman with painless enlarging gingival mass (Head Neck Pathol 2010;4:242)
- 33 year old woman with painful leg lesion (Dermatol Online J 2007;13:14)
Clinical images
Images hosted on other servers:
Tender, solitary firm papule
Microscopic (histologic) description
Images hosted on PathOut servers:
Cutaneous, courtesy of Mark R. Wick, M.D.
Images hosted on other servers:
Lower leg lesion
Gingival lesion is well demarcated
Thick, short collagen bundles and focal myxoid areas
S100
NSE
Positive stains
- S100 (sporadic)
Differential diagnosis
- Myxoid neurofibroma: S100+ (strong)
- Perineurioma
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