Soft tissue
Peripheral nerve
Pacinian neurofibroma

Author: Vijay Shankar, M.D. (see Authors page)

Revised: 19 September 2016, last major update November 2012

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Pacinian neurofibroma

Cite this page: Pacinian neurofibroma. website. Accessed April 26th, 2017.
Definition / General
  • Rare neurofibroma with proliferation of structures resembling Pacinian (Vater-Pacini) corpuscles
  • Pacinian corpuscle is also called Vater-Pacini corpuscle (Wikipedia - Abraham Vater); is a skin mechanoreceptor responsible for sensitivity to pain and pressure (Wikipedia - Lamellar corpuscle)
  • Initially described as Neuroma of Wagner-Meissner tactile corpuscles (Cancer 1951;4:879)
  • Very rare
  • Fingers, hands and feet; also buttocks, very rarely in the oral cavity
  • Buttock lesions may be associated with skeletal anomalies
  • Occurs as a solitary nodule, can be polypoid, ulcerated or plaque like
  • Some cases may be nerve sheath myxoma / neurothekeoma
Diagrams / Tables

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Normal Pacinian corpuscle

Pacinian corpuscle labeled at bottom

Case Reports
Clinical Images

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Micro Description
  • Round or oval corpuscles with multiple concentric lamellae
  • Lack the perfect structure of a Vater-Pacini corpuscle
Micro Images

Images hosted on PathOut servers:

A: mucinous nature is evident
B: tumor contains nerve fibers and delicate spindle cells focally arranged in parallel configurations similar to Pacinian corpuscles (C)
Source: AFIP Fascicle, 3rd series

Images hosted on other servers:

Above row: normal Pacinian corpuscles
Below row: pacinian neurofibroma

Elliptical or spindle-shaped nuclei

Pacinian corpuscle-like formations

Differential Diagnosis
  • Nerve sheath myxoma / neurothekeoma: less resemblance to Vater-Pacini corpuscles; stromal mucin is present
  • Pacinian neuroma / pacinioma / hyperplasia of pacinian corpuscles: rare, hamartomatous overgrowth, no neurofibroma component to lesion; often pain and tenderness at site; may be associated with trauma (Am J Dermatopathol 2006;28:202)