Soft tissue
Peripheral nerve
Pacinian neurofibroma

Topic Completed: 1 November 2012

Revised: 22 March 2019

Copyright: 2002-2018,, Inc.

PubMed Search: Pacinian neurofibroma

Vijay Shankar, M.D.
Page views in 2018: 1,598
Page views in 2019 to date: 1,354
Cite this page: Shankar V. Pacinian neurofibroma. website. Accessed October 18th, 2019.
Definition / general
  • Rare neurofibroma with proliferation of structures resembling Pacinian (Vater-Pacini) corpuscles
  • Pacinian corpuscle is also called Vater-Pacini corpuscle (Wikipedia - Abraham Vater); is a skin mechanoreceptor responsible for sensitivity to pain and pressure (Wikipedia - Lamellar corpuscle)
  • Initially described as Neuroma of Wagner-Meissner tactile corpuscles (Cancer 1951;4:879)
  • Very rare
  • Fingers, hands and feet; also buttocks, very rarely in the oral cavity
  • Buttock lesions may be associated with skeletal anomalies
  • Occurs as a solitary nodule, can be polypoid, ulcerated or plaque like
  • Some cases may be nerve sheath myxoma / neurothekeoma
Diagrams / tables

Images hosted on other servers:

Normal Pacinian corpuscle

Pacinian corpuscle labeled at bottom

Case reports
Clinical images

Images hosted on other servers:


Microscopic (histologic) description
  • Round or oval corpuscles with multiple concentric lamellae
  • Lack the perfect structure of a Vater-Pacini corpuscle
Microscopic (histologic) images

Images hosted on PathOut servers:

A: mucinous nature is evident
B: tumor contains nerve fibers and delicate spindle cells focally arranged in parallel configurations similar to Pacinian corpuscles (C)
Source: AFIP Fascicle, 3rd series

Images hosted on other servers:

Above row: normal Pacinian corpuscles
Below row: pacinian neurofibroma

Elliptical or spindle-shaped nuclei

Pacinian corpuscle-like formations

Differential diagnosis
  • Nerve sheath myxoma / neurothekeoma: less resemblance to Vater-Pacini corpuscles; stromal mucin is present
  • Pacinian neuroma / pacinioma / hyperplasia of pacinian corpuscles: rare, hamartomatous overgrowth, no neurofibroma component to lesion; often pain and tenderness at site; may be associated with trauma (Am J Dermatopathol 2006;28:202)
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