Soft tissue
Peripheral nerve
Pigmented neurofibroma

Topic Completed: 1 November 2012

Revised: 22 March 2019

Copyright: 2002-2018,, Inc.

PubMed Search: Pigmented neurofibroma

Vijay Shankar, M.D.
Page views in 2018: 849
Page views in 2019 to date: 660
Cite this page: Shankar V. Pigmented neurofibroma. website. Accessed September 22nd, 2019.
Definition / general
  • Head and neck, buttock or leg are most common sites
Clinical features
  • Variable association with neurofibromatosis
  • Median age 28 years, range 2 - 61 years
Case reports
  • Excision, do not recur
Clinical images

Images hosted on other servers:

Above eyelid

Gross description
  • No gross pigmentation
Microscopic (histologic) description
  • Classic features of neurofibroma with loosely arranged tumor cells containing scant cytoplasm, elongated nuclei; also melanin pigment
  • Shows differentiation toward mature melanin production, but melanin synthesis appears to be impaired (Hum Pathol 2005;36:871)
Microscopic (histologic) images

Images hosted on other servers:

Above eyelid

Dermal spindle cell tumor

Loosely arranged tumor cells; pigment in inset

In NF1


MelanA +

Positive stains
Negative stains
Differential diagnosis
  • Cellular blue nevus: not associated with neurofibroma; cells have nevoid features, not neural features
  • Congenital neuronevus: has junctional activity and nevoid component
  • Melanotic schwannoma: not associated with neurofibroma; biphasic, rounded nuclei, diffusely S100+
  • Neurocristic hamartoma: complex proliferation of nevomelanocytes
  • Pigmented dermatofibrosarcoma protuberans: more extensive storiform pattern, CD34 (strong), S100 negative
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