Skin nonmelanocytic tumor
Neural tumors
Neurothekeoma


Topic Completed: 1 November 2012

Minor changes: 16 October 2020

Copyright: 2002-2020, PathologyOutlines.com, Inc.

PubMed Search: Neurothekeoma [title] soft tissue

Vijay Shankar, M.D.
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Cite this page: Shankar V. Neurothekeoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/softtissueneurothekeoma.html. Accessed October 29th, 2020.
Definition / general
  • Superficial tumor, first described in 1980
  • Originally, derivation thought to be from nerve sheath; now thought to derive from fibroblasts with ability to differentiate into myofibroblasts and to recruit histiocytes (Am J Surg Pathol 2007;31:1103)
Sites
  • Usually head, upper extremities or shoulder girdle
Clinical features
  • Solitary, superficial, slow growing mass up to 2 cm
  • 60% women, mean age 17 years (range 2 - 85 years), 80% are < age 30 at initial diagnosis
Case reports
Treatment
  • Excision, may recur
Clinical images

Images hosted on other servers:

Thumb nodule

Lower back

Lower eyelid

Microscopic (histologic) description
  • Cellular, myxoid or mixed subtypes
  • Involves dermis or subcutis
  • Multinodular mass with myxoid matrix and peripheral fibrosis
  • Whorled or focally fascicular patterns of spindled and epithelioid mononuclear cells with abundant cytoplasm, indistinct cell borders
  • Margins usually positive; usually occasional multinucleated giant cells
  • Variable nuclear atypia
  • Median 4 MF / 25 HPF, may have 10+ MF / 25 HPF, may be atypical
Microscopic (histologic) images

Images hosted on PathOut servers:
Courtesy of Mark R. Wick, M.D.:

MiTF

Cellular type



Cellular type, skin



Images hosted on other servers:

Left thumb nodule of 5 month old boy

Lower eyelid of elderly man

Positive stains
Negative stains
Differential diagnosis
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