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Soft tissue
Fibroblastic / myofibroblastic tumors
Nodular fasciitis

Reviewer: Daniel Wimmer, D.O. (see Reviewers page)
Editor: Jerad M. Gardner, M.D.
Revised: 28 August 2014, last major update June 2013
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.

See subtypes below: cranial fasciitis, intravascular fasciitis, proliferative funiculitis

General
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Epidemiology
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Case reports
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Treatment
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Clinical images
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Mammogram, courtesy of Dr. Mark R. Wick
Gross description
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Gross images
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Scapular lesion
Micro description
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Micro images
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Images from AFIP:
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Fig 1: Subcutaneous tumor is partially circumscribed nodule infiltrating focally along fascial planes
Fig 2: Focal infiltration into fat, with evenly distributed granulation tissue-like vessels throughout the lesion
Fig 3: Gently curving C and S shaped fascicles of myofibroblastic cells exhibit a characteristic "torn Kleenex" pattern
Fig 4: Focal storiform pattern is suggestive of fibrous histiocytoma
Fig 5: Plump spindled myofibroblastic cells and extravasated red blood cells

Figure 6
Figure 7
Figure 8
Cystic degeneration
Fig 6: Mitotic figures but no abnormal forms
Fig 7: Focally more collagenous stroma with skeletal muscle involvement
Fig 8: Osteoclastic giant cells are present in less collagenous areas, suggesting a variant of MFH

Figure 9
Figure 10
Figure 11
Fig 9: Hyalinized variant resembles keloid or fibromatosis
Fig 10: Vague zonation pattern with bone formation in lower right
Fig 11: Island of new bone surrounded by myofibroblastic cells


Other images:
Leg lesion
Leg lesion-5 resembles fibroblast culture
Figure 1
Figure 2
Fig 1: Myofibroblasts and staghorn blood vessels
Fig 2: "Tram track" pattern of actin expression in myofibroblasts

Case of the Week #65 / tumor of wrist:
Cytology description
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Positive stains
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Negative stains
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Electron microscopy description
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Molecular / cytogenetics description
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Differential diagnosis
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Cranial fasciitis

Reviewer: Ricardo M. Mendoza, M.D. (see Reviewers page)
Editor: Jerad M. Gardner, M.D.

Definition
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Epidemiology
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Sites
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Pathophysiology
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Etiology
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Clinical features
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Radiology
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Case reports
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Treatment
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Gross description
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Micro description
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Micro images
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Resembles usual nodular fasciitis
Spindle cells lack cytologic atypia
Increased mitotic activity
Positive stains
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Negative stains
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Differential diagnosis
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Intravascular fasciitis

Reviewer: Lauren N. Stuart, M.D., M.B.A. (see Reviewers page)
Editor: Jerad M. Gardner, M.D.

Definition
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Epidemiology
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Sites
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Etiology
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Case reports
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Treatment
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Gross description
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Micro description
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Micro images
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AFIP:
Large focus of nodular fasciitis protrudes into vascular space
Cellular proliferation has edematous background characteristic of nodular fasciitis

Other:
Intravascular proliferation of uniform spindle cells
Low power, H&E
High power, H&E
Initial biopsy
Re-excision
Positive stains
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Negative stains
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Differential diagnosis
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Proliferative funiculitis

Reviewer: Lauren N. Stuart, M.D., M.B.A. (see Reviewers page)
Editor: Jerad M. Gardner, M.D.

Definition
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Terminology
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Epidemiology
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Sites
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Etiology
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Clinical features
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Laboratory
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Radiology
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Prognostic factors
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Treatment
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Gross description
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Gross / clinical images
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Inguinal tumor
Tumor in undescended testis
Micro description
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Micro images
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Spindle cell proliferation
Positive stains
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Negative stains
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Differential diagnosis
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End of Soft tissue > Fibroblastic / myofibroblastic tumors > Nodular fasciitis


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