Soft tissue
Fibroblastic / myofibroblastic
Ossifying fibromyxoid tumor

Topic Completed: 1 June 2013

Minor changes: 10 September 2020

Copyright: 2002-2020,, Inc.

PubMed Search: Ossifying fibromyxoid tumor [title]

Jerad M. Gardner, M.D.
Page views in 2019: 3,371
Page views in 2020 to date: 2,816
Cite this page: Gullett A. Ossifying fibromyxoid tumor. website. Accessed October 25th, 2020.
Definition / general
Clinical features
  • Adults, median age 50 years (range 14 - 83 years), no sex predilection
  • Presents with small painless mass, most commonly lower extremity, but in any soft tissue location including head and neck
  • Usually histologically benign with benign clinical course; local recurrences in 17%, malignant behavior in 5%
  • Histologically malignant OFMTs are high-grade sarcomas with distant metastases and adverse outcome in up to 60% of patients
  • May have neuroectodermal origin due to CD56+, CD99+ (Int J Surg Pathol 2007;15:437, Am J Surg Pathol 2011;35:1615)
Radiology images

Contributed by Mark R. Wick, M.D.

CT, chest wall

Prognostic factors
Case reports
  • Excision
Gross description
Microscopic (histologic) description
  • Nests / cords of round / oval cells, primarily epithelioid, with indistinct cytoplasm in fibromyxoid to hyalinized matrix
  • Lobulated at low power
  • Surrounded by partial shell of lamellar and woven bone and collagenous pseudocapsule
  • Minimal atypia and minimal mitotic figures, but may have necrosis, vascular invasion or high nuclear grade
Microscopic (histologic) images

Contributed by Mark R. Wick, M.D.

Various images

Case #348

56 year old man

Images hosted on other servers:

Occipital scalp lesion

Cytology description
  • Clusters, cords or small aggregates of round, polygonal or spindle cells in myxoid background with osteoid-like material (Diagn Cytopathol 2004;30:41)
  • Malignant cases may show significant nuclear pleomorphism with coarse chromatin, irregular contours and 1 - 2 distinct nucleoli (Acta Cytol 2001;45:745)
Positive stains
Negative stains
Electron microscopy description
Molecular / cytogenetics description
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