Soft tissue
Fibroblastic / myofibroblastic tumors
Ossifying fibromyxoid tumor

Author: Ashley Gullett, M.D. (see Authors page)
Editor: Jerad M. Gardner, M.D.

Revised: 29 August 2016, last major update June 2013

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Ossifying fibromyxoid tumor [title]

Cite this page: Ossifying fibromyxoid tumor. website. Accessed October 22nd, 2016.
Definition / General
Clinical Features
  • Adults, median age 50 years (range 14 - 83 years), no sex predilection
  • Presents with small painless mass, most commonly lower extremity, but in any soft tissue location including head and neck
  • Usually histologically benign with benign clinical course; local recurrences in 17%, malignant behavior in 5%
  • Histologically malignant OFMTs are high-grade sarcomas with distant metastases and adverse outcome in up to 60% of patients
  • May have neuroectodermal origin due to CD56+, CD99+ (Int J Surg Pathol 2007;15:437, Am J Surg Pathol 2011;35:1615)
Prognostic Factors
Case Reports
  • Excision
Clinical Images

Images hosted on PathOut servers:

CT, chest wall, courtesy of Mark R. Wick, M.D.

Gross Description
Micro Description
  • Nests / cords of round / oval cells, primarily epithelioid, with indistinct cytoplasm in fibromyxoid to hyalinized matrix
  • Lobulated at low power
  • Surrounded by partial shell of lamellar and woven bone and collagenous pseudocapsule
  • Minimal atypia and minimal mitotic figures, but may have necrosis, vascular invasion or high nuclear grade
Micro Images

Images hosted on PathOut servers:

Courtesy of Mark R. Wick, M.D.

Case of the Week #348 - 56 year old man

Images hosted on other servers:

Ossifying fibromyxoid tumor

Caption unknown

Lobules of uniform rounded cells

Occipital scalp lesion

Cytology Description
  • Clusters, cords or small aggregates of round, polygonal or spindle cells in myxoid background with osteoid-like material (Diagn Cytopathol 2004;30:41)
  • Malignant cases may show significant nuclear pleomorphism with coarse chromatin, irregular contours and 1 - 2 distinct nucleoli (Acta Cytol 2001;45:745)
Positive Stains
Negative Stains
Electron Microscopy Description
Molecular / Cytogenetics Description