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Table of Contents
Definition / general | Case reports | Clinical images | Gross description | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Negative stains | Electron microscopy description | Electron microscopy images | Molecular / cytogenetics descriptionCite this page: Shankar, V. Perineurioma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/softtissueperineurioma.html. Accessed April 25th, 2018.
Definition / general
- Uncommon benign tumor of peripheral nerve composed primarily of perineurial cells, first described in 1978
- Adults, more common in females
- Extremities and trunk most common sites
Case reports
- 23 year old man with median nerve tumor (Hand (N Y) 2010;5:286)
- 30 year old man with thigh mass and neurofibromatosis 2 (Am J Surg Pathol 2006;30:1624)
- 53 year old woman with endobronchial tumor (Patholog Res Int 2010;2010:613824)
- 63 year old man with retroperitoneal mass (J Med Case Rep 2010;4:290)
Clinical images
Images hosted on other servers:
Endobronchial nodule
Finger
Gross description
- Well circumscribed, variable size, usually NOT associated with a nerve
Microscopic (histologic) description
- Bland, elongated cells in parallel bundles, resembles neurofibroma or pacinian neurofibroma; may have storiform growth
- May have collagenous stroma with pericellular cracking / clefting
- No atypia, rare mitotic figures
- Suspect if myxoid lesion of soft tissue with storiform or fascicular growth pattern
Microscopic (histologic) images
Images hosted on PathOut servers:
Cutaneous, courtesy of Mark R. Wick, M.D.
EMA, courtesy of Mark R. Wick, M.D.
Images hosted on other servers:
Median nerve
Retroperitoneum
Site unknown
Endobronchial nodule in 53 year old woman
Negative stains
Electron microscopy description
- Non-branching, thin cytoplasmic processes, coated by external lamina, joined at ends by tight junctions, few organelles, actin and vimentin filaments, numerous pinocytotic vesicles
Electron microscopy images
Images hosted on PathOut servers:
Courtesy of Mark R. Wick, M.D.
Molecular / cytogenetics description
- Monosomy 22, deletion of 22q11-13.1
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