Soft tissue
Peripheral nerve

Author: Vijay Shankar, M.D.

Revised: 30 January 2018 last major update November 2012

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Perineurioma [title]

See also: reticular, sclerosing

Cite this page: Shankar, V. Perineurioma. website. Accessed March 21st, 2018.
Definition / general
  • Uncommon benign tumor of peripheral nerve composed primarily of perineurial cells, first described in 1978
  • Adults, more common in females
  • Extremities and trunk most common sites
Case reports
Clinical images

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Endobronchial nodule


Gross description
  • Well circumscribed, variable size, usually NOT associated with a nerve
Microscopic (histologic) description
  • Bland, elongated cells in parallel bundles, resembles neurofibroma or pacinian neurofibroma; may have storiform growth
  • May have collagenous stroma with pericellular cracking / clefting
  • No atypia, rare mitotic figures
  • Suspect if myxoid lesion of soft tissue with storiform or fascicular growth pattern
Microscopic (histologic) images

Images hosted on PathOut servers:

Cutaneous, courtesy of Mark R. Wick, M.D.

EMA, courtesy of Mark R. Wick, M.D.

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Median nerve


Site unknown

Endobronchial nodule in 53 year old woman

Positive stains
Negative stains
Electron microscopy description
  • Non-branching, thin cytoplasmic processes, coated by external lamina, joined at ends by tight junctions, few organelles, actin and vimentin filaments, numerous pinocytotic vesicles
Electron microscopy images

Images hosted on PathOut servers:

Courtesy of Mark R. Wick, M.D.

Molecular / cytogenetics description
  • Monosomy 22, deletion of 22q11-13.1