Soft tissue
Peripheral nerve
Other benign
Perineurioma
Author: Vijay Shankar, M.D.
Topic Completed: 1 November 2012
Minor changes: 22 October 2020
Copyright: 2002-2020, PathologyOutlines.com, Inc.
PubMed Search: Perineurioma [title]
Table of Contents
Definition / general | Case reports | Clinical images | Gross description | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Negative stains | Electron microscopy description | Electron microscopy images | Molecular / cytogenetics descriptionCite this page: Shankar V. Perineurioma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/softtissueperineurioma.html. Accessed October 24th, 2020.
Definition / general
- Uncommon benign tumor of peripheral nerve composed primarily of perineurial cells, first described in 1978
- Adults, more common in females
- Extremities and trunk most common sites
Case reports
- 23 year old man with median nerve tumor (Hand (N Y) 2010;5:286)
- 30 year old man with thigh mass and neurofibromatosis 2 (Am J Surg Pathol 2006;30:1624)
- 53 year old woman with endobronchial tumor (Patholog Res Int 2010;2010:613824)
- 63 year old man with retroperitoneal mass (J Med Case Rep 2010;4:290)
Clinical images
Images hosted on other servers
Endobronchial nodule
Gross description
- Well circumscribed, variable size, usually NOT associated with a nerve
Microscopic (histologic) description
- Bland, elongated cells in parallel bundles, resembles neurofibroma or pacinian neurofibroma; may have storiform growth
- May have collagenous stroma with pericellular cracking / clefting
- No atypia, rare mitotic figures
- Suspect if myxoid lesion of soft tissue with storiform or fascicular growth pattern
Microscopic (histologic) images
Contributed by Mark R. Wick, M.D.
Cutaneous
EMA
Images hosted on other servers:
Median nerve
Retroperitoneum
Site unknown
Endobronchial nodule in 53 year old woman
Negative stains
Electron microscopy description
- Non-branching, thin cytoplasmic processes, coated by external lamina, joined at ends by tight junctions, few organelles, actin and vimentin filaments, numerous pinocytotic vesicles
Electron microscopy images
Contributed by Mark R. Wick, M.D.
Perineurioma
Molecular / cytogenetics description
- Monosomy 22, deletion of 22q11-13.1
