Perineurioma

Soft tissue
Peripheral nerve
Perineurioma

Author: Vijay Shankar, M.D.

Revised: 15 May 2018 last major update November 2012

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Perineurioma [title]

See also: reticular, sclerosing

Table of Contents

Cite this page: Shankar, V. Perineurioma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/softtissueperineurioma.html. Accessed August 15th, 2018.

Definition / general

Uncommon benign tumor of peripheral nerve composed primarily of perineurial cells, first described in 1978
Adults, more common in females
Extremities and trunk most common sites

Case reports

23 year old man with median nerve tumor (Hand (N Y) 2010;5:286)
30 year old man with thigh mass and neurofibromatosis 2 (Am J Surg Pathol 2006;30:1624)
53 year old woman with endobronchial tumor (Patholog Res Int 2010;2010:613824)
63 year old man with retroperitoneal mass (J Med Case Rep 2010;4:290)

Clinical images

Images hosted on other servers:

Endobronchial nodule

Gross description

Well circumscribed, variable size, usually NOT associated with a nerve

Microscopic (histologic) description

Bland, elongated cells in parallel bundles, resembles neurofibroma or pacinian neurofibroma; may have storiform growth
May have collagenous stroma with pericellular cracking / clefting
No atypia, rare mitotic figures
Suspect if myxoid lesion of soft tissue with storiform or fascicular growth pattern

Microscopic (histologic) images

Images hosted on PathOut servers:

Cutaneous, courtesy of Mark R. Wick, M.D.

EMA, courtesy of Mark R. Wick, M.D.

Images hosted on other servers:

Median nerve

Retroperitoneum

Site unknown

Endobronchial nodule in 53 year old woman

Positive stains

EMA, CD34 (33%)

Negative stains

S100

Electron microscopy description

Non-branching, thin cytoplasmic processes, coated by external lamina, joined at ends by tight junctions, few organelles, actin and vimentin filaments, numerous pinocytotic vesicles

Electron microscopy images

Images hosted on PathOut servers:

Courtesy of Mark R. Wick, M.D.

Molecular / cytogenetics description

Monosomy 22, deletion of 22q11-13.1