Soft tissue
Peripheral nerve

Author: Vijay Shankar, M.D. (see Authors page)

Revised: 21 September 2016, last major update November 2012

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Perineurioma [title]

See also: reticular, sclerosing

Cite this page: Perineurioma. website. Accessed October 21st, 2016.
Definition / General
  • Uncommon benign tumor of peripheral nerve composed primarily of perineurial cells, first described in 1978
  • Adults, more common in females
  • Extremities and trunk most common sites
Case Reports
Clinical Images

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Endobronchial nodule


Gross Description
  • Well circumscribed, variable size, usually NOT associated with a nerve
Micro Description
  • Bland, elongated cells in parallel bundles, resembles neurofibroma or pacinian neurofibroma; may have storiform growth
  • May have collagenous stroma with pericellular cracking / clefting
  • No atypia, rare mitotic figures
  • Suspect if myxoid lesion of soft tissue with storiform or fascicular growth pattern
Micro Images

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Cutaneous, courtesy of Mark R. Wick, M.D.

EMA, courtesy of Mark R. Wick, M.D.

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Median nerve


Site unknown

Endobronchial nodule in 53 year old woman

Positive Stains
Negative Stains
Electron Microscopy Description
  • Non-branching, thin cytoplasmic processes, coated by external lamina, joined at ends by tight junctions, few organelles, actin and vimentin filaments, numerous pinocytotic vesicles
Electron Microscopy Images

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Courtesy of Mark R. Wick, M.D.

Molecular / Cytogenetics Description
  • Monosomy 22, deletion of 22q11-13.1