Soft tissue
Smooth muscle
Pleomorphic leiomyosarcoma

Author: Vijay Shankar, M.D. (see Authors page)

Revised: 29 September 2016, last major update November 2012

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Pleomorphic leiomyosarcoma

Cite this page: Pleomorphic leiomyosarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/softtissuepleomorphicleiomyosarcoma.html. Accessed December 3rd, 2016.
Definition / General
  • Pleomorphic areas should be at least 2/3 of tumor
Epidemiology
  • 10% of all leiomyosarcomas
  • Mean age 58 years, range 31 - 89 years
Clinical Features
  • Usually extremities, also retroperitoneum / abdominal cavity, chest / abdominal wall, occasionally scalp
  • May be more aggressive than ordinary leiomyosarcoma, as 65% die of disease
Case Reports
Micro Description
  • Focally fascicular with smooth muscle tumor cells
  • Pleomorphic areas mimic MFH-pleomorphic
  • Storiform pattern common
  • Stromal hyalinization, chronic inflammatory infiltrate
  • Usually high grade
  • Occasionally rhabdoid features
Micro Images

Images hosted on other servers:

Various images

Resembles MFH

Abrupt transition from fascicular to pleomorphic areas

Positive Stains
Differential Diagnosis