Soft tissue
Smooth muscle
Pleomorphic leiomyosarcoma

Topic Completed: 1 November 2012

Minor changes: 26 March 2019

Copyright: 2002-2018,, Inc.

PubMed Search: Pleomorphic leiomyosarcoma

Vijay Shankar, M.D.
Page views in 2019: 1,736
Page views in 2020 to date: 588
Cite this page: Shankar V. Pleomorphic leiomyosarcoma. website. Accessed May 27th, 2020.
Definition / general
  • Pleomorphic areas should be at least 2/3 of tumor
  • 10% of all leiomyosarcomas
  • Mean age 58 years, range 31 - 89 years
Clinical features
  • Usually extremities, also retroperitoneum / abdominal cavity, chest / abdominal wall, occasionally scalp
  • May be more aggressive than ordinary leiomyosarcoma, as 65% die of disease
Case reports
Microscopic (histologic) description
  • Focally fascicular with smooth muscle tumor cells
  • Pleomorphic areas mimic MFH-pleomorphic
  • Storiform pattern common
  • Stromal hyalinization, chronic inflammatory infiltrate
  • Usually high grade
  • Occasionally rhabdoid features
Microscopic (histologic) images

Images hosted on other servers:

Various images

Resembles MFH

Abrupt transition from fascicular to pleomorphic areas

Positive stains
Differential diagnosis
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