Soft tissue
Smooth muscle
Leiomyosarcoma with rhabdoid features

Author: Vijay Shankar, M.D.

Revised: 31 January 2018, last major update November 2012

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Leiomyosarcoma [title] rhabdoid features

Cite this page: Shankar, V. Leiomyosarcoma with rhabdoid features. website. Accessed March 23rd, 2018.
Definition / general
  • Diffuse proliferation of rhabdoid cells in otherwise identifiable leiomyosarcoma
  • Tumors with scattered rhabdoid cells may be better classified as pleomorphic leiomyosarcoma
  • Distinct from rhabdoid tumor of kidney
Case reports
  • Presence of rhabdoid cells in a tumor, in general, is associated with aggressive behavior
  • Poorer prognosis for external soft tissue (not intra-abdominal) cases, but not for retroperitoneal cases (Mod Pathol 2000;13:1211)
Gross description
  • 3 - 22 cm
Microscopic (histologic) description
  • Rhabdoid cells are large and polygonal with eosinophilic cytoplasm, eosinophilic globular perinuclear inclusions, eccentric nuclei and prominent nucleoli
Microscopic (histologic) images

Images hosted on PathOut servers:

Composite rhabdomyosarcoma-
leiomyosarcoma, courtesy of
Mark R. Wick, M.D.

Images hosted on other servers:




Positive stains
Electron microscopy description
  • Paranuclear aggregates or whorls of intermediate filaments
Molecular / cytogenetics description
Molecular / cytogenetics images

Images hosted on other servers:

Normal 22q dosages

Differential diagnosis