Soft tissue
Smooth muscle
Leiomyosarcoma with rhabdoid features

Topic Completed: 1 November 2012

Revised: 26 March 2019

Copyright: 2002-2018,, Inc.

PubMed Search: Leiomyosarcoma [title] rhabdoid features

Vijay Shankar, M.D.
Page views in 2019: 377
Page views in 2020 to date: 22
Cite this page: Shankar V. Leiomyosarcoma with rhabdoid features. website. Accessed February 19th, 2020.
Definition / general
  • Diffuse proliferation of rhabdoid cells in otherwise identifiable leiomyosarcoma
  • Tumors with scattered rhabdoid cells may be better classified as pleomorphic leiomyosarcoma
  • Distinct from rhabdoid tumor of kidney
Case reports
  • Presence of rhabdoid cells in a tumor, in general, is associated with aggressive behavior
  • Poorer prognosis for external soft tissue (not intra-abdominal) cases, but not for retroperitoneal cases (Mod Pathol 2000;13:1211)
Gross description
  • 3 - 22 cm
Microscopic (histologic) description
  • Rhabdoid cells are large and polygonal with eosinophilic cytoplasm, eosinophilic globular perinuclear inclusions, eccentric nuclei and prominent nucleoli
Microscopic (histologic) images

Images hosted on PathOut server:

Contributed by Mark R. Wick, M.D.

Composite rhabdomyosarcoma-leiomyosarcoma

Positive stains
Electron microscopy description
  • Paranuclear aggregates or whorls of intermediate filaments
Molecular / cytogenetics description
Differential diagnosis
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