Soft tissue
Smooth muscle
Leiomyosarcoma with rhabdoid features

Author: Vijay Shankar, M.D. (see Authors page)

Revised: 29 September 2016, last major update November 2012

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Leiomyosarcoma [title] rhabdoid features

Cite this page: Leiomyosarcoma with rhabdoid features. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/softtissuerhabdoidleiomyosarcoma.html. Accessed September 23rd, 2017.
Definition / general
  • Diffuse proliferation of rhabdoid cells in otherwise identifiable leiomyosarcoma
  • Tumors with scattered rhabdoid cells may be better classified as pleomorphic leiomyosarcoma
  • Distinct from rhabdoid tumor of kidney
Epidemiology
Case reports
Treatment
  • Presence of rhabdoid cells in a tumor, in general, is associated with aggressive behavior
  • Poorer prognosis for external soft tissue (not intra-abdominal) cases, but not for retroperitoneal cases (Mod Pathol 2000;13:1211)
Gross description
  • 3 - 22 cm
Microscopic (histologic) description
  • Rhabdoid cells are large and polygonal with eosinophilic cytoplasm, eosinophilic globular perinuclear inclusions, eccentric nuclei and prominent nucleoli
Microscopic (histologic) images

Images hosted on PathOut servers:

Composite rhabdomyosarcoma-
leiomyosarcoma, courtesy of
Mark R. Wick, M.D.



Images hosted on other servers:

Thigh

Retroperitoneum

Thigh-stains

Positive stains
Electron microscopy description
  • Paranuclear aggregates or whorls of intermediate filaments
Molecular / cytogenetics description
Molecular / cytogenetics images

Images hosted on other servers:

Normal 22q dosages

Differential diagnosis