Soft tissue
Uncertain differentiation
Rhabdoid tumor


Topic Completed: 1 November 2012

Revised: 5 September 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed search: Rhabdoid tumor [title] soft tissue

Related topics: Rhabdoid tumor of the kidney

Vijay Shankar, M.D.
Page views in 2018: 4,507
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Cite this page: Shankar V. Rhabdoid tumor. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/softtissuerhabdoidtumor.html. Accessed October 21st, 2019.
Definition / general
  • Kidney, soft tissue, other sites
  • Usually infants / children
  • Probably represents emergence of an aggressive phenotype of various tumors (epithelioid sarcoma, intraabdominal desmoplastic round cell tumor, rhabdomyosarcoma, melanoma, carcinoma)
  • Early metastases to lung, liver, lymph nodes
  • Very aggressive, poor response to therapy, usually fatal
Case reports
Gross images
Images hosted on PathOut server:

Superficial, subcuticular, courtesy of Dr. Mark R. Wick

Microscopic (histologic) description
  • Solid sheets of large cells with deep eosinophilic cytoplasm, possible laterally displaced nucleus, prominent nucleoli
  • Myxoid, hyalinized, pseudoalveolar areas
Microscopic (histologic) images
Images hosted on PathOut server:

Various images, courtesy of Dr. Mark R. Wick

INI1, courtesy of Dr. Mark R. Wick

Extra renal, courtesy of Dr. Mark R. Wick



Images hosted on other servers:

Vulvar tumor (loss of INI1, ER+)

Lung tumor

Cytology images
Images hosted on PathOut server:

FNAB, courtesy of Dr. Mark R. Wick



Images hosted on other servers:

Abdominal mass

Positive stains
Negative stains
Electron microscopy description
  • Prominent intermediate filaments
Molecular / cytogenetics description
  • Characterized by genetic loss of SMARCB1 (SNF5, INI1), a component of the SWI / SNF chromatin remodeling complex (Lab Invest 2010;90:724)
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