Soft tissue
Other tumors
Rhabdoid tumor

Author: Vijay Shankar, M.D. (see Authors page)

Revised: 15 November 2016, last major update November 2012

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed search: Rhabdoid tumor [title] soft tissue

Related topics: Rhabdoid tumor of the kidney
Cite this page: Rhabdoid tumor. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/softtissuerhabdoidtumor.html. Accessed December 7th, 2016.
Definition / General
  • Kidney, soft tissue, other sites
  • Usually infants / children
  • Probably represents emergence of an aggressive phenotype of various tumors (epithelioid sarcoma, intraabdominal desmoplastic round cell tumor, rhabdomyosarcoma, melanoma, carcinoma)
  • Early metastases to lung, liver, lymph nodes
  • Very aggressive, poor response to therapy, usually fatal
Case Reports
Gross Images
Images hosted on PathOut server:

Superficial, subcuticular, courtesy of Dr. Mark R. Wick

Micro Description
  • Solid sheets of large cells with deep eosinophilic cytoplasm, possible laterally displaced nucleus, prominent nucleoli
  • Myxoid, hyalinized, pseudoalveolar areas
Micro Images
Images hosted on PathOut server:

Various images, courtesy of Dr. Mark R. Wick

INI1, courtesy of Dr. Mark R. Wick

Extra renal, courtesy of Dr. Mark R. Wick



Images hosted on other servers:

Vulvar tumor (loss of INI1, ER+)

Lung tumor

Cytology Images
Images hosted on PathOut server:

FNAB, courtesy of Dr. Mark R. Wick



Images hosted on other servers:

Abdominal mass

Positive Stains
Negative Stains
Electron Microscopy Description
  • Prominent intermediate filaments
Molecular / Cytogenetics Description
  • Characterized by genetic loss of SMARCB1 (SNF5, INI1), a component of the SWI / SNF chromatin remodeling complex (Lab Invest 2010;90:724)