Soft tissue
Other tumors
Sinus histiocytosis with massive lymphadenopathy




Topic Completed: 1 November 2012

Revised: 27 March 2019

Copyright: 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Sinus histiocytosis with massive lymphadenopathy [title]
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Cite this page: Shankar V. Sinus histiocytosis with massive lymphadenopathy. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/softtissuesinushistiocytosis.html. Accessed May 20th, 2019.
Definition / general
  • Also known as Rosai-Dorfman disease
  • May present as soft tissue mass with nodal involvement in 25%
  • Usually women, mean 46 years, range 24 - 66 years
  • Usually extremities (52%), also trunk (26%), head and neck (13%), retroperitoneum (9%)
  • May recur after surgery
  • Difficult diagnosis in non nodal tissue
Case reports
Gross images
Images hosted on other servers:

Contributed by Dr. Semir Vranic, University of Sarajevo (USA):

Thigh lesion

Microscopic (histologic) description
  • Large histiocytic cells, frequently spindled, with less conspicuous emperipolesis than nodal lesions; fibroinflammatory component (Am J Surg Pathol 1992;16:122)
Microscopic (histologic) images
Images hosted on PathOut server:

Courtesy of Dr. Mark R. Wick



Images hosted on other servers:

Cervical lymph node



Extranodal - Contributed by Dr. Semir Vranic, University of Sarajevo (USA):

Subcutaneous right thigh

CD68

S100

Cytology images
Images hosted on other servers:

Cervical lymph node

Positive stains
Differential diagnosis
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