Soft tissue
Other tumors
Sinus histiocytosis with massive lymphadenopathy

Author: Vijay Shankar, M.D. (see Authors page)

Revised: 15 September 2016, last major update November 2012

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: Sinus histiocytosis with massive lymphadenopathy [title]

Cite this page: Sinus histiocytosis with massive lymphadenopathy. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/softtissuesinushistiocytosis.html. Accessed December 7th, 2016.
Definition / General
  • Also known as Rosai-Dorfman disease
  • May present as soft tissue mass with nodal involvement in 25%
  • Usually women, mean 46 years, range 24 - 66 years
  • Usually extremities (52%), also trunk (26%), head and neck (13%), retroperitoneum (9%)
  • May recur after surgery
  • Difficult diagnosis in non nodal tissue
Case Reports
Gross Images
Images hosted on other servers:

Contributed by Dr. Semir Vranic, University of Sarajevo (USA):

Thigh lesion

Micro Description
  • Large histiocytic cells, frequently spindled, with less conspicuous emperipolesis than nodal lesions; fibroinflammatory component (Am J Surg Pathol 1992;16:122)
Micro Images
Images hosted on PathOut server:

Courtesy of Dr. Mark R. Wick



Images hosted on other servers:

Cervical lymph node



Extranodal - Contributed by Dr. Semir Vranic, University of Sarajevo (USA):

Subcutaneous right thigh

CD68

S100

Cytology Images
Images hosted on other servers:

Cervical lymph node

Positive Stains
Differential Diagnosis