Soft tissue
Skeletal muscle
Skeletal muscle - normal




Topic Completed: 1 November 2012

Revised: 26 March 2019

Copyright: 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Skeletal muscle [title] soft tissue

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Cite this page: Shankar V. Skeletal muscle - normal. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/softtissueskeletalnormal.html. Accessed May 20th, 2019.
Definition / general
  • Normal skeletal muscle arises from mesectoderm in head and neck and from myotomes (group of skeletal muscles supplied by a specific segmental spinal nerve), and elsewhere via formation of myoblasts and myotubes (muscle fibers)
  • Contains myofibrils composed of thin (actin) and thick (myosin) filaments
Terminology
  • Skeletal muscle cells are also called myofibers or myocytes
Diagrams / tables

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Various images



Section of myofibrils with sarcoplasmic
reticulum (SR) and T-tubules (T)

Microscopic (histologic) description
  • Long cylindrical cells, unbranched and striated
  • Multinucleated syncytia, formed by fusion of single cells
  • Nuclei are peripheral to the myofiber
Microscopic (histologic) images

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Various images

Longitudinal and transverse sections

Skeletal muscle vasculature


Normal striated muscle

Electron microscopy description
  • Electron microscopy reveals structural components:
  • I (isotropic) band: thin filaments only
  • A (anisotropic) band: overlapping thin and thick filaments
  • H band: thick filaments only
  • Z line: divides center of I band; serves as attachment site for the sarcomere, the repeating individual unit of the muscle fiber
Electron microscopy images

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Various images

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