Soft tissue
Smooth muscle
Smooth muscle tumors - general

Topic Completed: 1 November 2012

Revised: 26 March 2019

Copyright: 2002-2018,, Inc.

PubMed Search: Smooth muscle tumors [title]

Vijay Shankar, M.D.
Page views in 2018: 1,137
Page views in 2019 to date: 1,202
Cite this page: Shankar V. Smooth muscle tumors - general. website. Accessed October 18th, 2019.
Microscopic (histologic) description
  • Tumor cells resemble smooth muscle with easily visible, often fibrillar and eosinophilic cytoplasm, usually in long bundles or fascicles
  • Nucleus is long, oval and round at both ends, often with cytoplasmic vacuole at one end, nucleoli are indistinct
  • Minimal collagen present between smooth muscle cells
  • Smooth muscle cells may resemble myofibroblasts with less cytoplasm, thinner nuclei, denser chromatin
  • Note: smooth muscle tumors of skin, vulva/vagina, scrotum, nipple and other locations are described in these chapters
Microscopic (histologic) images

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Smooth muscle



Positive stains
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