Soft tissue
Fibroblastic / myofibroblastic
Superficial acral fibromyxoma


Topic Completed: 1 April 2013

Minor changes: 10 September 2020

Copyright: 2002-2020, PathologyOutlines.com, Inc.

PubMed Search: Superficial acral fibromyxoma

Lauren N. Stuart, M.D., M.B.A.
Jerad M. Gardner, M.D.
Page views in 2019: 7,541
Page views in 2020 to date: 4,364
Cite this page: Stuart L. Superficial acral fibromyxoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/softtissuesuperficialacral.html. Accessed September 20th, 2020.
Definition / general
  • Name is accurate - superficial tumor of fingers and toes with bland fibromyxoid histology
  • First described in 2001 (Hum Pathol 2001;32:704)
Terminology
Epidemiology
Sites
Clinical features
Prognostic factors
  • Local recurrence almost always associated with positive margins
Case reports
Treatment
Gross description
  • Well circumscribed, non encapsulated gray-white nodule
  • Can be dome shaped, polypoid, verrucous
  • Cut surface firm, gelatinous, solid (Arch Pathol Lab Med 2011;135:1064)
Microscopic (histologic) description
  • Dermal or subcutaneous tumor composed of bland spindle and stellate cells within a myxoid or collagenous stroma with prominent vessels and mast cells
  • Cells are arranged in random, loose storiform and fascicular growth patterns
  • Mild nuclear atypia
  • Occasional multinuclear stromal cells
  • Rare mitotic figures
Microscopic (histologic) images

Images hosted on other servers:

Tumor at tip of big toe

Spindle cells and mast cells in myxoid matrix (fig1)

CD34+ (fig2)

CD99+ (fig3)

H&E, CD10 and nestin

Positive stains
Differential diagnosis
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