Soft tissue
Fibroblastic / myofibroblastic tumors
Superficial acral fibromyxoma

Author: Lauren N. Stuart, M.D., M.B.A.
Editor: Jerad M. Gardner, M.D.

Revised: 16 May 2018, last major update April 2013

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Superficial acral fibromyxoma

Page views in 2018: 6,220
Page views in 2019 to date: 964
Cite this page: Stuart, L.N. Superficial acral fibromyxoma. website. Accessed February 15th, 2019.
Definition / general
  • Name is accurate - superficial tumor of fingers and toes with bland fibromyxoid histology
  • First described in 2001 (Hum Pathol 2001;32:704)
Clinical features
Prognostic factors
  • Local recurrence almost always associated with positive margins
Case reports
Gross description
  • Well circumscribed, non encapsulated gray-white nodule
  • Can be dome shaped, polypoid, verrucous
  • Cut surface firm, gelatinous, solid (Arch Pathol Lab Med 2011;135:1064)
Microscopic (histologic) description
  • Dermal or subcutaneous tumor composed of bland spindle and stellate cells within a myxoid or collagenous stroma with prominent vessels and mast cells
  • Cells are arranged in random, loose storiform and fascicular growth patterns
  • Mild nuclear atypia
  • Occasional multinuclear stromal cells
  • Rare mitotic figures
Microscopic (histologic) images

Images hosted on other servers:

Tumor at tip of big toe

Spindle cells and mast cells in myxoid matrix (fig1)

CD34+ (fig2)

CD99+ (fig3)

Spindle cell proliferation

H&E, CD10 and nestin

Positive stains
Differential diagnosis