Soft tissue
Infections, inflammation and hematomas
Tumoral calcinosis

Author: Komal Arora, M.D.

Revised: 28 January 2018, last major update July 2012

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Tumoral calcinosis [title]

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Cite this page: Arora, K. Tumoral calcinosis. website. Accessed February 16th, 2019.
Definition / general
  • Definition: large painless calcified masses in periarticular soft tissues, including elbows, hips, only rarely knees
  • Also called calcium hydroxyapatite deposition in soft tissue, metastatic calcification
  • Usage is imprecise - also refers to hereditary condition associated with massive periarticular calcification and any massive collection of periarticular calcification (Radiographics 2006;26:871)
Clinical features
  • Elevated serum calcium, phosphate and Vitamin D
  • Local recurrence common
Radiology description
  • Lobulated calcifications, separate from associated bone
Gross description
  • Large, multinodular, chalky masses
Microscopic (histologic) description
  • Lobules of calcific material surrounded by histiocytic giant cells often containing small psammomatous calcifications
Microscopic (histologic) images

Images hosted on other servers:

Figures 2a and 2b: Calcification with foreign body inflammation

Courtesy of John Irlam, D.O

Differential diagnosis
  • Dystrophic calcification: contains dead tissue that is not rapidly absorbed; associated with coagulation necrosis, caseous necrosis, fat necrosis
Additional references