Soft tissue
Infections, inflammation and hematoma
Tumoral calcinosis


Topic Completed: 1 July 2012

Minor changes: 10 September 2020

Copyright: 2002-2020, PathologyOutlines.com, Inc.

PubMed Search: Tumoral calcinosis [title]

Komal Arora, M.D.
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Cite this page: Arora K. Tumoral calcinosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/softtissuetumoralcalcinosis.html. Accessed November 27th, 2020.
Definition / general
  • Definition: large painless calcified masses in periarticular soft tissues, including elbows, hips, only rarely knees
  • Also called calcium hydroxyapatite deposition in soft tissue, metastatic calcification
  • Usage is imprecise - also refers to hereditary condition associated with massive periarticular calcification and any massive collection of periarticular calcification (Radiographics 2006;26:871)
Clinical features
Laboratory
  • Elevated serum calcium, phosphate and Vitamin D
  • Local recurrence common
Radiology description
  • Lobulated calcifications, separate from associated bone
Gross description
  • Large, multinodular, chalky masses
Microscopic (histologic) description
  • Lobules of calcific material surrounded by histiocytic giant cells often containing small psammomatous calcifications
Microscopic (histologic) images

Contributed by John Irlam, D.O.

Calcinosis



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Figures 2a and 2b: Calcification with foreign body inflammation

Differential diagnosis
  • Dystrophic calcification: contains dead tissue that is not rapidly absorbed; associated with coagulation necrosis, caseous necrosis, fat necrosis
Additional references
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Image 01 Image 02