Soft tissue
Infections, inflammation and hematomas
Tumoral calcinosis

Author: Komal Arora, M.D. (see Authors page)

Revised: 27 July 2016, last major update July 2012

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Tumoral calcinosis [title]

Cite this page: Tumoral calcinosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/softtissuetumoralcalcinosis.html. Accessed December 9th, 2016.
Definition / General
  • Definition: large painless calcified masses in periarticular soft tissues, including elbows, hips, only rarely knees
  • Also called calcium hydroxyapatite deposition in soft tissue, metastatic calcification
  • Usage is imprecise - also refers to hereditary condition associated with massive periarticular calcification and any massive collection of periarticular calcification (Radiographics 2006;26:871)
Clinical Features
Laboratory
  • Elevated serum calcium, phosphate and Vitamin D
  • Local recurrence common
Radiology Description
  • Lobulated calcifications, separate from associated bone
Gross Description
  • Large, multinodular, chalky masses
Micro Description
  • Lobules of calcific material surrounded by histiocytic giant cells often containing small psammomatous calcifications
Micro Images

Images hosted on other servers:

Figures 2a and 2b: Calcification with foreign body inflammation

Courtesy of John Irlam, D.O

Differential Diagnosis
  • Dystrophic calcification: contains dead tissue that is not rapidly absorbed; associated with coagulation necrosis, caseous necrosis, fat necrosis
Additional References