Infectious / inflammatory disorders
Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 9 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
- Prior to highly active antiretroviral therapy (HAART), typical findings were white pulp depletion, hemosiderin deposition, spindle cell proliferation and perivascular hyalinization; also infectious and malignant infiltrates (Mod Pathol 2002;15:406)
- Post-HAART findings include less frequent white pulp depletion, but similar rates of splenic involvement by atypical mycobacteria and CMV in those with systemic disease
Normal spleen with abundant white pulp|
Mild white-pulp depletion|
Moderate white-pulp depletion|
Marked white-pulp depletion|
Large cell lymphoma|
End of Spleen > Infectious / inflammatory disorders > AIDS
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